ID K7GGI6_PELSI Unreviewed; 836 AA.
AC K7GGI6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSPSIP00000019397.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019397.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019397.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; AGCU01168297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01168306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006135481.1; XM_006135419.2.
DR AlphaFoldDB; K7GGI6; -.
DR STRING; 13735.ENSPSIP00000019397; -.
DR Ensembl; ENSPSIT00000019488.1; ENSPSIP00000019397.1; ENSPSIG00000017167.1.
DR GeneID; 102455600; -.
DR KEGG; pss:102455600; -.
DR CTD; 83857; -.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000158027; -.
DR HOGENOM; CLU_011615_1_1_1; -.
DR OMA; TRWHTWR; -.
DR OrthoDB; 155869at2759; -.
DR TreeFam; TF328339; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 2.
DR SMART; SM00386; HAT; 4.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 246..318
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 437..470
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 502..535
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 536..569
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 570..603
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 637..670
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 705..738
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 743..776
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 777..810
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 836 AA; 94951 MW; A92AF1335451D66D CRC64;
MNPFYFHAVN VILHCLVTLV LMYTCDKAVF KDGRLAFVTA LFFAVHPIHS EAVTGIVGRA
DVLACLLFLL AFLSYTRSVD QFYVGEHFPP TASPFFLLLS LFLGTCAMLV KETGVTVFGV
CLIYDLLFLS YNRLRLSNGG VHQRFLRQPA ASASASLQIP PSSRENGKHR YAHKGTWNSC
HPASPEVQRS SSLSVSNKAV WAILSYLTAS NNKNFLYTAR PFLKRAALVI SYVILVLYFR
LWIMGGSMPM FSEQDNPASF SPYLLTRFLT YSYLLAFNAW LLLAPITLCY DWQVGSIPLI
ESIWDVRNLA TVLLVMVMIL LSLHCITAFK KLEHREVLVG LLFLVFPFIP ASNLFFRVGF
VVAERILYMP SMGYCILFVH GLKKLCAWLN RWGTTVLTLS ALLLLLLFSW KTVRQNEIWL
SRESLFSSGV QTLPHNAKVH YNYANFLKDQ GRNSGAIYHY KTALRLYPRH ASALNNLGTL
TKDLVEAKEY YRRALQLNPQ HNRALFNLGN LLKSQGKKEE AVFLLRDSIK YGPEFADAYS
SLASLLAEQE QFKEAQEVYQ AGIENCPESS DLHNNYGVFL VDTGAPERAV SHYQQAIWLS
PNHYVAMVNL GRLYRSLGEN KEAEAWYKRA LKVSRKAEIL SPLGALYYNT GRYEEALQVY
REAAALQPSN KEIRLALAQV LAMMGQTKEA EKMTNHIVTE DAECLECYRL LSAIYSKQEH
YSKALEAIDK ALQLKPKDPK VISELFFTKG NQLREQNLLD KAFESYKLSV ELNPDQAQAW
MNMGGIEHIK GDYVTARSYY KKALQLVPNS KLLKENLAKL DRLEKRLQEI QGKDQT
//
