ID K7GH34_PELSI Unreviewed; 522 AA.
AC K7GH34;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Calcium uptake protein 1, mitochondrial {ECO:0000256|ARBA:ARBA00040181};
GN Name=MICU1 {ECO:0000313|Ensembl:ENSPSIP00000019595.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019595.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion intermembrane
CC space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000256|ARBA:ARBA00038333}.
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DR EMBL; AGCU01146498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01146507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GH34; -.
DR STRING; 13735.ENSPSIP00000019595; -.
DR Ensembl; ENSPSIT00000019686.1; ENSPSIP00000019595.1; ENSPSIG00000017389.1.
DR eggNOG; KOG2643; Eukaryota.
DR GeneTree; ENSGT00950000183079; -.
DR HOGENOM; CLU_027103_3_1_1; -.
DR OMA; GGPMYMT; -.
DR TreeFam; TF313815; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:1990246; C:uniplex complex; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IEA:Ensembl.
DR GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
DR GO; GO:1900069; P:regulation of cellular hyperosmotic salinity response; IEA:Ensembl.
DR CDD; cd16173; EFh_MICU1; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294:SF1; CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12294; EF HAND DOMAIN FAMILY A1,A2-RELATED; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 264..299
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 454..489
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 105..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 59737 MW; 124FC16ACA2438C2 CRC64;
MRFAILGLGG KKGKVMKNCI AFVMWHLLQY LTVAIYFPHL IRMFRLRVLA TVAGLGAISR
GYHGMAHLTR SRQRLMMAAF IGATAATASA GLLWKRAYAE ASSSVKHNAR TEANEKVKDQ
EEENGEDDRR TIESNGGGTQ PEEKKKKQRS GFRDRKVMEY ENRIRAYSTP DKIFRYFATL
KVINEHGESE VFMTPQDFVR SITPNEKQPE HLGLDQFVVK RYDGKKLSQE REKFADEDSI
FYTLGECGLI SFSDYIFLTT VLSTPQRNFE IAFKMFDLNG DGEVDMEEFE QVQSIIRSQT
CMGMRHRDRS TTGNTLKTGF SSALTTYFFG SDLKGKLTIS NFLEFQRKLQ HDVLKLEFER
HDPANGRITE RQFGGMLLAY SGVQSKKLTL MLKQLRKHFQ DGEGLTFEEV ESFFTFLKNI
NDVDTALSFY HMAGASLDKV TMQQVARTVA KVELSDHVCD VVFALFDCDG NGEMSNKEFV
AIMKQRLMRG LEKPKDMGFT RLMRAMWKCA QETAWDFAMP KQ
//
