ID K7GI39_PELSI Unreviewed; 1078 AA.
AC K7GI39;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Semaphorin 6D {ECO:0000313|Ensembl:ENSPSIP00000019950.1};
GN Name=SEMA6D {ECO:0000313|Ensembl:ENSPSIP00000019950.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000019950.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000019950.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AGCU01166401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01166402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K7GI39; -.
DR STRING; 13735.ENSPSIP00000019950; -.
DR Ensembl; ENSPSIT00000020044.1; ENSPSIP00000019950.1; ENSPSIG00000017665.1.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159303; -.
DR HOGENOM; CLU_009051_2_0_1; -.
DR OMA; EAYNHAX; -.
DR TreeFam; TF316102; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:Ensembl.
DR GO; GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0014909; P:smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1078
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003902936"
FT TRANSMEM 663..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..512
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 625..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1028..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 120454 MW; C0A683DA66220365 CRC64;
MRLLLLCACV ILLTVSQSLA VSFPEDDDPI NVVDYHYSRQ YPVFKGRPSG NESQHRLDFQ
LMLKIRDTLY IAGRDQVYTV NLNEVPKSEV TPSKKLTWRS RQQDRENCAM KGKHKDECHN
FIKVFVPRND EMVFVCGTNA FNPMCRYYWL NTLEYDGEEI SGLARCPFDA RQTNVALFAD
GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI
AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI
TDIIEINGVP TVVGVFTTQL NRIQTTIVLA FLLDDIEKVF KGRFKEQKTP DSVWTAVPED
KVPKPRPGCC AKHGLAEAYK TSIDFPDETL SFIKSHPLMD SAIPSVIEEP WFTKTRVRYR
LTAVAVDHLA GPYQNYTVIF VGSEAGVILK ILAKTRPFSL NDSVLLEEID AYNHAKCNSE
SEEDRKVISL QLDKEHHAVF VAFSSCVIRI PLSRCERHGS CKKSCIASRD PYCGWLDQGV
CGRVKPSMFT GGYEQDVEYG NTGQLGDCHE ILPTTTTPDY KIFGDPTSDM ELSTASITTM
ASIPVIAPKV TGSWKPKVTG SRKFVVQDDP NTSDNPDPLS GVPKGVRWEV QAGDSNQMVH
MNVLITCVFA AFVVGAFLAG VAVYCYRDLF VRKSRKIHKD AESAQSCTDS SGSFAKLNGL
FDSPIKEYQQ NIDSPKLYTN LLSSRKELPP SGDTKSMIMD HRGQPPELAA LPTPESTPVL
QQKTLQVMKS QSDKAHSNLN TSRKETPLKS PQFFPSSPPP HSPLSHGHIP SAIVLPNATH
DYNMSFSNSN AHKADKKMQN IEHPLTKPSS KRDHRKSVDS RNTLNDFLKH LNETPNNPKS
IMGDIQVAHQ TLMLDPMGNM SEIPPKVPNR EASLYSPPST LPRNSPTKRV DVPTTPAVPM
TSLERQRGYH KNSSQRHSIS ALPKNLNSPN GVLLSRQPSI TRGGYMPPAT GTKMDYMQGT
PVSVHLQPSL SRQSSYTSNG TLPRTGIKRT PSIKPDVPPK PSFVPQTTSV RPLNKYSY
//
