ID K7GK38_PELSI Unreviewed; 920 AA.
AC K7GK38;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Bromodomain containing 8 {ECO:0000313|Ensembl:ENSPSIP00000020649.1};
GN Name=BRD8 {ECO:0000313|Ensembl:ENSPSIP00000020649.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000020649.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000020649.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGCU01075741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01075742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01075743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01075744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_014428307.1; XM_014572821.1.
DR STRING; 13735.ENSPSIP00000020649; -.
DR Ensembl; ENSPSIT00000020746.1; ENSPSIP00000020649.1; ENSPSIG00000018266.1.
DR GeneID; 102461791; -.
DR KEGG; pss:102461791; -.
DR CTD; 10902; -.
DR eggNOG; ENOG502QRPS; Eukaryota.
DR GeneTree; ENSGT00530000064262; -.
DR HOGENOM; CLU_007253_0_0_1; -.
DR OMA; AYKPHTT; -.
DR OrthoDB; 2919186at2759; -.
DR TreeFam; TF106422; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:Ensembl.
DR GO; GO:0000812; C:Swr1 complex; IEA:Ensembl.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:Ensembl.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:Ensembl.
DR GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Ensembl.
DR GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR CDD; cd05507; Bromo_brd8_like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR InterPro; IPR037966; Brd8_Bromo_dom.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR PANTHER; PTHR15398; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR15398:SF4; BROMODOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267}.
FT DOMAIN 766..836
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 201..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 67..94
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 644..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 99032 MW; 35DE111B1D975BDA CRC64;
MRSGDQNWVS VSRAIKPFAE PGRPPDWFSQ KHCASQYSEL LETTETPKRK RGEKGEVVET
VEDVIVRKLT AERVEELKKM IKETQEKYRQ LKKDSELIQA GHMDSRLEEL CNDIVVKKKM
EEEEAEMKRK ATDAAYQARQ AVKNPPRRLT GVMVRSPAGS TSPGRDYVLG DLSQQAVEET
SPGVMMLPMV TPGTLPSTPV ASFIGIPDTP PGSAPLDAPI TPVTDDSPQK KMLGQKATPP
PSPLLSELLK KGSLLPTSPR LVGESEMAVA SGHMNSSGVL LEVGGVLPVL HGGEMQLASG
AIPASPAASG APTLSRLLEA GPAQFTTPLA SFSAVASETP AKLLPPPVES VSQATIVMMP
TLSAPSVVPP SATPESVVTG SQSDTCVSME AVSDPHTVTV SMDSSEISMI IDSIKKECLG
GGIGSTAGPS KDHTMDGKED LDLAEKMGIA VSYTGEELDF ETVGDIIAII EDKGDDHPEV
LDVAAVEAAL SFCEETDDPQ ALTGXXXXHE QQAQIPQVAV TVKQERQDSE EPEAKEIQDL
ISIGDLGSEI KTESEELEQN ELDSEEAAVA AVQIAETPEL RSQETEELQK AAAIMGENSK
AETESAKGGE AAAAAHSTVK IEMLPDDDSS PTHVPSASDD SSQADVQHKF ELSESLKEET
RAAFGKDAQG EDDDEDGASE AASLEEPKEE DQGEGYLSEM DNEPPVSESD DGFSIHNAPL
QSHTLADSIP SSPASSQFSV CSEDQEAIQA QKIWKKAIML VWRAAANHRY ANVFLQPVTD
DIAPGYHSIV QRPMDLSTIK KNIENGLIRT TAEFQRDIML MFQNAVMYNS SDHDVYHMAV
EMQRDVLEQI QQFLATQLIM QTSESGISAK SLRGRDSTRK QDASEKDSVP MGSPAFLLSL
FDGGTRGRRC AIEADMKMKK
//
