ID K7GN13_PIG Unreviewed; 1478 AA.
AC K7GN13;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Nuclear factor of activated T cells 5 {ECO:0000313|Ensembl:ENSSSCP00000029262.4};
GN Name=NFAT5 {ECO:0000313|Ensembl:ENSSSCP00000029262.4,
GN ECO:0000313|VGNC:VGNC:90708};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000029262.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000029262.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029262.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000029262.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9823.ENSSSCP00000029262; -.
DR PaxDb; 9823-ENSSSCP00000002973; -.
DR Ensembl; ENSSSCT00000034601.4; ENSSSCP00000029262.4; ENSSSCG00000002755.6.
DR VGNC; VGNC:90708; NFAT5.
DR GeneTree; ENSGT00940000155213; -.
DR HOGENOM; CLU_912045_0_0_1; -.
DR InParanoid; K7GN13; -.
DR OrthoDB; 5405363at2759; -.
DR ChiTaRS; NFAT5; pig.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000002755; Expressed in omentum and 42 other cell types or tissues.
DR ExpressionAtlas; K7GN13; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IBA:GO_Central.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1904996; P:positive regulation of leukocyte adhesion to vascular endothelial cell; IEA:Ensembl.
DR GO; GO:0062176; P:R-loop processing; IEA:Ensembl.
DR GO; GO:0070884; P:regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 282..461
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 58..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1269..1313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1478 AA; 160199 MW; 1B78AC3436421EDD CRC64;
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP KELQLPPSRE
TSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS SFTTSSSPTI YSTSVTDSKA
MQVESCSSAL GVSNRGVSEK QLTSNTVQQH PSTPKRHTVL YISPPPEDLL DNSRMSCQDE
GCGLESEQSC SMWMEDSPSN FSNMSTSSYN DNTEVPRKSR KRNPKQRPGV KRRDCEESNM
DIFDADSAKA PHYVLSQLTT DNKGNSKAGN GTLENQKGAG VKKSPMLCGQ YPVKSEGKEL
KIVVQPETQH RARYLTEGSR GSVKDRTQQG FPTVKLEGHN EPVVLQVFVG NDSGRVKPHG
FYQACRVTGR NTTPCKEVDI EGTTVIEVGL DPSNNMTLAV DCVGILKLRN ADVEARIGIA
GSKKKSTRAR LVFRVNITRK DGSTLTLQTP SSPILCTQPA GVPEILKKSL HSCSVKGEEE
VFLIGKNFLK GTKVIFQENV SDENSWKSEA EIDMELFHQM KTTGCNLDKV MLPNALITPL
ISSSMIKSED VTPMEVTAEK RSSPIFKAAK TVGSTQQTLD NISNIAGNGS FSSSSSSHLP
SENEKQQQIQ PKTYNPETLT TIQTQDISQP GTFPAVSASS QLPTGDALLQ QATQFQTRET
PSREVLQSDG SVVNLTHLAE ASQQQQQSPL QEQAQTLQQQ ISSNIFPSPN SVSQLQNTIQ
QLQAGSFTGS TASGSNGNVD LVQQVLEAQQ QLSSVLFSAP DSNENVQEQL SADIFQQVSQ
IQNSVSPGMF SSTEPAVHTR PDNLIAGRAE SVHPQTENAL SNQQQQQQQQ QVMESSAAMV
MEMQQSICQA AAQIQSELFP STGSANGNLQ QSPVYQQTSH MMSALSTNED MQMQCELFSS
PPAVSGNETA TTTTQQVATP GTTMFQTSSS GDGEETGAQA KQIQNSVFQT MVQMQHSGDS
QPQVNLFSST KSIMNVQNSG TQQQGNGLFQ QGNEMMSLQS GNFLQQSSHS QAQLFHPQNP
IADAQNLSQE TQGSIFHNPN PIVRSQTSTT SSEQMQPPMF HSQSTMAVLQ GSSVPQDQQS
ANIFLSQSPM NNLQTNTVAQ EEQISFFAAQ NSISPLQSTS NTEQQAAFQQ QAPISHIQTP
MLSQEQAQPS QQGLFQPQVS LGSLPPNPIP QNQQGTIFQS QHSMVAIQSN SPSQEQQQQQ
QQQQQQQQQQ QQQSILFSNQ NTMATMASQK QPPPNMIFNP SQNPMANQEQ QNQSIFHQQN
NIAQMNQEQQ PMQFQNQPTV SSLQNPGPAQ SESSQTSLFH SSPQIQLVQG SPSSQEQQVT
LFLSPASMSA LQNSINQQDM QQSPLYSSQN NIPGIQGATS SPQPQATLFH NTTGGTMNQL
QNSPGSSQQT SGMFLFGIQN NCNPLLTSGP ATLPDQLMAI SQPGQPQNEN QPPVTTLLSQ
QMPENSPLTS SLNTNQNIEK IDLLVSLQNQ GNNLTGSF
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