ID K7GNL4_PIG Unreviewed; 379 AA.
AC K7GNL4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Hydroxysteroid dehydrogenase-like protein 2 {ECO:0000256|ARBA:ARBA00040243};
GN Name=HSDL2 {ECO:0000313|Ensembl:ENSSSCP00000029469.3,
GN ECO:0000313|VGNC:VGNC:88992};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000029469.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000029469.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029469.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000029469.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has apparently no steroid dehydrogenase activity.
CC {ECO:0000256|ARBA:ARBA00037788}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; K7GNL4; -.
DR PeptideAtlas; K7GNL4; -.
DR Ensembl; ENSSSCT00000034705.4; ENSSSCP00000029469.3; ENSSSCG00000005467.6.
DR VGNC; VGNC:88992; HSDL2.
DR eggNOG; KOG0725; Eukaryota.
DR eggNOG; KOG4170; Eukaryota.
DR GeneTree; ENSGT00940000156729; -.
DR HOGENOM; CLU_010194_25_0_1; -.
DR Proteomes; UP000008227; Chromosome 1.
DR Bgee; ENSSSCG00000005467; Expressed in psoas major muscle and 44 other cell types or tissues.
DR ExpressionAtlas; K7GNL4; baseline.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd09762; HSDL2_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003033; SCP2_sterol-bd_dom.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR42808; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR42808:SF3; HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF02036; SCP2; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 1: Evidence at protein level;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Proteomics identification {ECO:0007829|PeptideAtlas:K7GNL4};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT DOMAIN 342..372
FT /note="SCP2"
FT /evidence="ECO:0000259|Pfam:PF02036"
FT REGION 291..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 41287 MW; 098933076F1E78E8 CRC64;
MQQWDFVGSQ RLAGCTVFIT GASRGIGKAI ALKAAKDGAN VVIAAKTTQT HPKLQGTIYT
AAEEIQAAGG KALPCVVDVR DEQQISDAVE KAVEKFGGID ILVNNASAIS LTNTLETPTK
RVDLMMNVNT RGTYLTSKAC IPYLKKSRIA HILNLSPPLN LNPLWFKQHC AYTIAKYGMS
MCVLGMAEEF KGEIAVNALW PKTAIHTAAM DMLGGSGIES QCRKVDIIAD AAYCIFKKPK
SFTGNFIIDE NILKEEGITN FDVYAVTPGH PLLPDFFLDE QPETVIKKME SHGADPELKK
EKLPPPPKPC SGAVEETFRI VKESLSDDVV KATQAIYQFE LSGKLKPVVA FLSGKLKIKG
NMALAIKLEK LMNQMNARL
//
