ID K7GQK8_PIG Unreviewed; 698 AA.
AC K7GQK8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 9.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Semaphorin 4D {ECO:0000313|Ensembl:ENSSSCP00000030178.2};
GN Name=SEMA4D {ECO:0000313|Ensembl:ENSSSCP00000030178.2,
GN ECO:0000313|VGNC:VGNC:92703};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000030178.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000030178.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000030178.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000030178.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; K7GQK8; -.
DR Ensembl; ENSSSCT00000034311.4; ENSSSCP00000030178.2; ENSSSCG00000009584.6.
DR VGNC; VGNC:92703; SEMA4D.
DR GeneTree; ENSGT00940000159594; -.
DR HOGENOM; CLU_009051_4_0_1; -.
DR OMA; PCLKFRS; -.
DR Proteomes; UP000008227; Chromosome 14.
DR Bgee; ENSSSCG00000009584; Expressed in prefrontal cortex and 44 other cell types or tissues.
DR ExpressionAtlas; K7GQK8; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11259; Sema_4D; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF18; SEMAPHORIN-4D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 1: Evidence at protein level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Proteomics identification {ECO:0007829|PeptideAtlas:K7GQK8};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..698
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012249174"
FT DOMAIN 19..500
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 591..690
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 553..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 698 AA; 76909 MW; 2599E6E4FF12FEB8 CRC64;
MRMRSPVWRL LTALAVVFGT AVAFAPIPRI TWEHREVQLV QFHEPGISNY SALLLSEDKD
TLYVGAREAV FALNAHNISR KQHEVYWKVS EDKKAKCAEK GKSKQTECLN YIRVLQPLSA
SALYVCGTNA FQPTCDHLNL TSFAFLGKNE DGKGRCPFDP AQSYTSVMVD GELYSGTSYN
FLGSEPIISR NSSHSPLRTE YAIPWLNEPS FVFADVMRES PGGGGGGDDR VYFFFTEVSV
EYEFVFKLLI PRVARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSNLVF NVLRDVFVLR
SPDLKEPVFY GVFTPQLNNV GLSAVCAYNL STAEAVFSRG KYMQSATVEQ SHTKWVRYNG
AVPTPRPGAC ITREARAANF SSSLNLPDKT LQFVKDHPLM DDSVTPIDGR PRLIKSDVNY
TQIVVDRTWA LDGTVHDVMF VSTDRGALHK AISLDNSVHI IEETQLFQDF EPVQTLLLSS
KEGRKFVYAG SNSGVVQAPL AFCGKHGTCQ DCVLARDPYC AWSPATAACI TLHQTDRPSR
GLIQEMNGDA SACPASSSLP LPPPGSSSLS CLGPDSSSSP RSPWPALGPG PDSHRQVTLL
PPFLGDQAQH VHALGTFHLF CQATGPADVH FLWEKNGRAL EVCVPMQTHV LPDGRAHVLS
WLRDAIRESA EYRCSALSSA GSRTSKVRVT VTRHGKLS
//
