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Database: UniProt
Entry: K7IYB2_NASVI
LinkDB: K7IYB2_NASVI
Original site: K7IYB2_NASVI 
ID   K7IYB2_NASVI            Unreviewed;       839 AA.
AC   K7IYB2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-APR-2018, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=LOC100116803 {ECO:0000313|EnsemblMetazoa:NV14086-PC};
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Terebrantes;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV14086-PC, ECO:0000313|Proteomes:UP000002358};
RN   [1] {ECO:0000313|EnsemblMetazoa:NV14086-PC}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV14086-PC};
RX   PubMed=20075255; DOI=10.1126/science.1178028;
RG   Nasonia Genome Working Group;
RA   Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J.,
RA   Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O.,
RA   Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G.,
RA   Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C.,
RA   Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M.,
RA   Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K.,
RA   Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M.,
RA   Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M.,
RA   Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P.,
RA   Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G.,
RA   Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B.,
RA   Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D.,
RA   Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G.,
RA   Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D.,
RA   Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M.,
RA   Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y.,
RA   Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L.,
RA   Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R.,
RA   Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D.,
RA   Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D.,
RA   Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V.,
RA   Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O.,
RA   Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R.,
RA   Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T.,
RA   Reid J.G., Riddle M., Robertson H.M., Romero-Severson J.,
RA   Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T.,
RA   Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L.,
RA   Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A.,
RA   Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A.,
RA   Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W.,
RA   Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M.,
RA   Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N.,
RA   Zhang L., Gibbs R.A.;
RT   "Functional and evolutionary insights from the genomes of three
RT   parasitoid Nasonia species.";
RL   Science 327:343-348(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:NV14086-PC}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   RefSeq; XP_001607798.1; XM_001607748.4.
DR   EnsemblMetazoa; NV14086-RC; NV14086-PC; NV14086.
DR   GeneID; 100116803; -.
DR   KEGG; nvi:100116803; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   KO; K02154; -.
DR   PhylomeDB; K7IYB2; -.
DR   Proteomes; UP000002358; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002358};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002358};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    397    420       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    440    465       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    534    555       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    567    587       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    646    665       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    764    789       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     71       {ECO:0000256|SAM:Coils}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   839 AA;  96769 MW;  62CC3B0CFD412FBC CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRYLEK EIKKDGIPML DTGENPEAPQ PREMIDLEAT FEKLENELRE VNLNAEALKR
     NFLELTELKH ILRKTQVFFD EMADPSREEE QVTLLGEEGL RAGGQALKLG FVAGVILRER
     IPAFERMLWR ACRGNVFLRQ AEIETPLEDP STGDQVHKSV FIIFFQGDQL KTRVKKICEG
     FRATLYPCPE APADRREMAM GVMTRIEDLN TVLGQTQDHR HRVLVAAAKN IKNWFIKVRK
     IKAIYHTLNL FNLDVTQKCL IAECWVPVLD IETIQLALRR GTERSGSSVP PILNRMETFE
     DPPTYNRTNK FTKGFQALID AYGVASYREM NPAPYTIITF PFLFAIMFGD FGHGLIMFLF
     GGWMVLKEKP LAAQKSDNEI WNIFFGGRYI IFLMGIFSMY TGFIYNDIFS KSLNVFGTYW
     TVTNITTDNV MNIKSFQLDP TWSYIQHPYP IGMDPVWQLA ENKIIFLNSY KMKISIIFGV
     IHMLFGVIVG LFNHLYFKRR INIICEFIPQ IIFLIFLFFY LTLLMFIKWV KYAAYHPIYN
     TDVKTSSYCA PSVLITFINM VLFKAPTQLP NCDEYMYGGE HFFERFLVLV GLLCIPWMLL
     AKPFMMMKER KKKHMQLNTH GTENGDIDGG VMQSQGGQMQ GGHKEEEEMS EVFIHQGIHT
     IEYVLGSVSH TASYLRLWAL SLAHAQLSEV LWNMVMKNGL TQEGWYGGIV LWAIFAFWAV
     LTVGILVLME GLSAFLHTLR LHWVEFQSKF YLGQGYSFTP FSFEIILETA QSATETVTD
//
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