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Database: UniProt
Entry: K7J2W7_NASVI
LinkDB: K7J2W7_NASVI
Original site: K7J2W7_NASVI 
ID   K7J2W7_NASVI            Unreviewed;      1086 AA.
AC   K7J2W7;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-JUN-2019, entry version 38.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=100122758 {ECO:0000313|EnsemblMetazoa:NV15693-PA};
OS   Nasonia vitripennis (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Parasitoida;
OC   Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia.
OX   NCBI_TaxID=7425 {ECO:0000313|EnsemblMetazoa:NV15693-PA, ECO:0000313|Proteomes:UP000002358};
RN   [1] {ECO:0000313|EnsemblMetazoa:NV15693-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AsymCX {ECO:0000313|EnsemblMetazoa:NV15693-PA};
RX   PubMed=20075255; DOI=10.1126/science.1178028;
RG   Nasonia Genome Working Group;
RA   Werren J.H., Richards S., Desjardins C.A., Niehuis O., Gadau J.,
RA   Colbourne J.K., Werren J.H., Richards S., Desjardins C.A., Niehuis O.,
RA   Gadau J., Colbourne J.K., Beukeboom L.W., Desplan C., Elsik C.G.,
RA   Grimmelikhuijzen C.J., Kitts P., Lynch J.A., Murphy T., Oliveira D.C.,
RA   Smith C.D., van de Zande L., Worley K.C., Zdobnov E.M., Aerts M.,
RA   Albert S., Anaya V.H., Anzola J.M., Barchuk A.R., Behura S.K.,
RA   Bera A.N., Berenbaum M.R., Bertossa R.C., Bitondi M.M.,
RA   Bordenstein S.R., Bork P., Bornberg-Bauer E., Brunain M.,
RA   Cazzamali G., Chaboub L., Chacko J., Chavez D., Childers C.P.,
RA   Choi J.H., Clark M.E., Claudianos C., Clinton R.A., Cree A.G.,
RA   Cristino A.S., Dang P.M., Darby A.C., de Graaf D.C., Devreese B.,
RA   Dinh H.H., Edwards R., Elango N., Elhaik E., Ermolaeva O., Evans J.D.,
RA   Foret S., Fowler G.R., Gerlach D., Gibson J.D., Gilbert D.G.,
RA   Graur D., Grunder S., Hagen D.E., Han Y., Hauser F., Hultmark D.,
RA   Hunter H.C. IV, Hurst G.D., Jhangian S.N., Jiang H., Johnson R.M.,
RA   Jones A.K., Junier T., Kadowaki T., Kamping A., Kapustin Y.,
RA   Kechavarzi B., Kim J., Kim J., Kiryutin B., Koevoets T., Kovar C.L.,
RA   Kriventseva E.V., Kucharski R., Lee H., Lee S.L., Lees K., Lewis L.R.,
RA   Loehlin D.W., Logsdon J.M. Jr., Lopez J.A., Lozado R.J., Maglott D.,
RA   Maleszka R., Mayampurath A., Mazur D.J., McClure M.A., Moore A.D.,
RA   Morgan M.B., Muller J., Munoz-Torres M.C., Muzny D.M., Nazareth L.V.,
RA   Neupert S., Nguyen N.B., Nunes F.M., Oakeshott J.G., Okwuonu G.O.,
RA   Pannebakker B.A., Pejaver V.R., Peng Z., Pratt S.C., Predel R.,
RA   Pu L.L., Ranson H., Raychoudhury R., Rechtsteiner A., Reese J.T.,
RA   Reid J.G., Riddle M., Robertson H.M., Romero-Severson J.,
RA   Rosenberg M., Sackton T.B., Sattelle D.B., Schluns H., Schmitt T.,
RA   Schneider M., Schuler A., Schurko A.M., Shuker D.M., Simoes Z.L.,
RA   Sinha S., Smith Z., Solovyev V., Souvorov A., Springauf A.,
RA   Stafflinger E., Stage D.E., Stanke M., Tanaka Y., Telschow A.,
RA   Trent C., Vattathil S., Verhulst E.C., Viljakainen L., Wanner K.W.,
RA   Waterhouse R.M., Whitfield J.B., Wilkes T.E., Williamson M.,
RA   Willis J.H., Wolschin F., Wyder S., Yamada T., Yi S.V., Zecher C.N.,
RA   Zhang L., Gibbs R.A.;
RT   "Functional and evolutionary insights from the genomes of three
RT   parasitoid Nasonia species.";
RL   Science 327:343-348(2010).
RN   [2] {ECO:0000313|EnsemblMetazoa:NV15693-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAR-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   RefSeq; XP_001606357.1; XM_001606307.4.
DR   STRING; 7425.NV15693-PA; -.
DR   EnsemblMetazoa; NV15693-RA; NV15693-PA; NV15693.
DR   GeneID; 100122758; -.
DR   KEGG; nvi:100122758; -.
DR   eggNOG; KOG0968; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   InParanoid; K7J2W7; -.
DR   KO; K02327; -.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   PhylomeDB; K7J2W7; -.
DR   Proteomes; UP000002358; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002358};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002358};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      109    459       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      524    953       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      991   1064       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     67       Disordered. {ECO:0000256|MobiDB-lite:
FT                                K7J2W7}.
FT   COMPBIAS     25     39       Acidic. {ECO:0000256|MobiDB-lite:K7J2W7}.
FT   COMPBIAS     45     61       Polar. {ECO:0000256|MobiDB-lite:K7J2W7}.
SQ   SEQUENCE   1086 AA;  123767 MW;  75AAD22FA92F7735 CRC64;
     MSKRSYSSPA VNKKTKNDEE PSTFESELAA MDDIEDEFFN EGTQIFGQGP EQENTSSKWS
     RPDPPALDPS KDTLCFQQID VDHYTDKPMP GMPGSRIGPV PVMRMYGVTE QGNSVCCHVH
     GFSPYFFVSA HPSFNNSHCK SFKEALNAAV KNDMKNNNDN IQDFILAVEI VERQTVYGYT
     GEKKSQFLKI TVALPRLIAP CKRLLETQVV FPTLDHKYTA YESNIDFDIR FMADTHMVGC
     SWIELKPGKW KLRGKHNHNM AQITRCQLEC DVAWDQFVAH APEGEWSKVA PFRILSFDIE
     CAGRKGIFPE PEHDPVIQIA NMVILQGESE PFLRNIFTLD TCAPIVGCQV LSFEKESSML
     EKWADFIRQL DPDIFTGYNI NNFDFPYLIN RAQHLHVRDF NYLGRIKNIR SVIKNQVLQS
     KQMGRRENKF VNFEGRVPFD LLLVLVRDYK LRSYTLNAVS YHFLQEQKED VHHSIISDLQ
     NGNAQTRRRL AVYCLKDAYL PLRLLDKLMC IIIYMEMARV TGVSLSSLLT RGQQIKVVSQ
     LLRKTIERGY LIPVHHGQGS DEQYEGATVI EPLRGYYNDP IATLDFSSLY PSIIMAHNIC
     YTTLLSPSAQ NHYNLSNDDI TRTPANSNFV KGSVRKGILP EILEQLLSAR KAAKADLKKE
     TDPLKQKVLD GRQYALKVSA NSVYGFTGAQ QGKLPCLEIS GSVTAYGRTM IEKTKQEVET
     HYRKENGYDH DAVVIYGDTD SVMVKFGVKK IEDAMKLGKE AAEYVTSKFI KPIKLEFEKV
     YFPYLLINKK RYAGLYFTKP DKYDKMDCKG LETVRRDNCP LVANMMNTCL QKLLIDRNPD
     DAMDYAKQII SDLLCNRIDI SQLVVTKELT KTDYTAKQAH VELAAKMKKR DAGTAPKLGD
     RIPYVFISGP KGVPAYQKAE DPIYVLENNI PIDTNYYLEN QLSKPLVRIF EPILGDKAES
     LLLKGEHTRT KSVATSKVGA LVAFTRKKEA CLGCKAVLAA DREGKALCQY CEEKEGQILQ
     NEIYNGRKLE EKFCRLWAEC QRCQGSLHQE VICTSRDCPI FYMRKKVQMD LDTQAKRIEK
     FGIPQW
//
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