ID K7N6R9_MOUSE Unreviewed; 851 AA.
AC K7N6R9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Vomeronasal 2, receptor 66 {ECO:0000313|Ensembl:ENSMUSP00000122645.2};
GN Name=Vmn2r66 {ECO:0000313|Ensembl:ENSMUSP00000122645.2,
GN ECO:0000313|MGI:MGI:3588220};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000122645.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000122645.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122645.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000122645.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122645.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; NP_001029050.3; NM_001033878.3.
DR AlphaFoldDB; K7N6R9; -.
DR SMR; K7N6R9; -.
DR STRING; 10090.ENSMUSP00000122645; -.
DR PaxDb; 10090-ENSMUSP00000122645; -.
DR PeptideAtlas; K7N6R9; -.
DR ProteomicsDB; 348755; -.
DR DNASU; 233437; -.
DR Ensembl; ENSMUST00000124773.3; ENSMUSP00000122645.2; ENSMUSG00000094950.3.
DR GeneID; 233437; -.
DR KEGG; mmu:233437; -.
DR UCSC; uc012foh.1; mouse.
DR AGR; MGI:3588220; -.
DR CTD; 233437; -.
DR MGI; MGI:3588220; Vmn2r66.
DR VEuPathDB; HostDB:ENSMUSG00000094950; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00950000183069; -.
DR HOGENOM; CLU_005389_5_0_1; -.
DR OrthoDB; 4188279at2759; -.
DR PhylomeDB; K7N6R9; -.
DR TreeFam; TF340115; -.
DR BioGRID-ORCS; 233437; 2 hits in 72 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; K7N6R9; Protein.
DR ExpressionAtlas; K7N6R9; differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06365; PBP1_pheromone_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF413; VOMERONASAL 2, RECEPTOR 66-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..851
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003908930"
FT TRANSMEM 583..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..794
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 800..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 580..844
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 851 AA; 97344 MW; 54B8E35184FD631A CRC64;
MFTLISVFWF LKISSIFCHL SDPRCFWRIK DTKNHLGDKE NNCFFSIYTK RGYVKNDYFS
CNLDKQVTPK TIHLIFSVYL AIEEINKDYH ILPNISLLVN IECDQRIYDK KSGLGLKSKE
IIPNYYCRNQ RRYLIVLTIP EWTVSTSLGP FLYISRIPEL YCGNFHLLLN DNEQFPHLYQ
ISPKDTSLPL AMVSLVVHFR WNWIGAIVTN DDHGIQFLSE LRGEMQKHIV CLSVAIIIQT
EKIMALKEFH THYNQIIMSS AKVVIVYGDK DSPIHFALIV WKSKGIWRIW VSVSQFDMIT
IIGDFLLYSS IGTFIFSHQQ PEIPGFEQFI QTVHPSNYSS EHSLAKLWWT YFRCSLPPSN
CKKLKNCPTT TVFKWLFMTP LGMAMSNTCY NLYNGVYAVA LSLHEMILQQ VDTWSMNAGK
ELEFDSWKLF YFLKTLQFVN PAGELVIMNQ NLKQDTEYDI FFIMDFKKYY GLKIKIGRFS
GHLPSGQQLL MSTEMIKWAT GIDQILPSVC SMPCRPGLRK SPQEGKDICC FVCYPCPENE
ISNMTNMDQC VKCPEDQYAN EDQTLCLQKV VAVLDYRDPL GKALAGFALC FSVLTSVVIC
VFLKHRETPI VKANNQTLSY VLLISLIFCF MSSLLYIGHP TMVICILQQT TFAIVFTVAA
STILAKTITV VLAFKATVPG RRMRWLLVSG APKYIILICT MVQLILCGIW LRISPPFVDA
DIHMLHGQII IVCNKGSVVA FYCVLGYMGS IALASFTVAF LARNLPHTFN EAKLLTFSML
VFCSVWITFI PVYHSTKGKT TVAVEVFCIL ASSAGLLLCI FAPKCYLILL RPQTNSFYKF
RRPHAKAENI S
//
