ID K7W4R5_9NOST Unreviewed; 998 AA.
AC K7W4R5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Signal transduction sensor and regulator protein {ECO:0000313|EMBL:AFW94744.1};
GN ORFNames=ANA_C11992 {ECO:0000313|EMBL:AFW94744.1};
OS Anabaena sp. 90.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Anabaena.
OX NCBI_TaxID=46234 {ECO:0000313|EMBL:AFW94744.1, ECO:0000313|Proteomes:UP000010101};
RN [1] {ECO:0000313|EMBL:AFW94744.1, ECO:0000313|Proteomes:UP000010101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=90 {ECO:0000313|EMBL:AFW94744.1};
RX PubMed=23148582; DOI=10.1186/1471-2164-13-613;
RA Wang H., Sivonen K., Rouhiainen L., Fewer D.P., Lyra C., Rantala-Ylinen A.,
RA Vestola J., Jokela J., Rantasarkka K., Li Z., Liu B.;
RT "Genome-derived insights into the biology of the hepatotoxic bloom-forming
RT cyanobacterium Anabaena sp. strain 90.";
RL BMC Genomics 13:613-613(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP003284; AFW94744.1; -; Genomic_DNA.
DR RefSeq; WP_015079905.1; NC_019427.1.
DR AlphaFoldDB; K7W4R5; -.
DR STRING; 46234.ANA_C11992; -.
DR KEGG; anb:ANA_C11992; -.
DR PATRIC; fig|46234.3.peg.2244; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG2770; Bacteria.
DR eggNOG; COG3706; Bacteria.
DR HOGENOM; CLU_300098_0_0_3; -.
DR OrthoDB; 9759607at2; -.
DR Proteomes; UP000010101; Chromosome chANA01.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 3.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF08447; PAS_3; 2.
DR Pfam; PF13188; PAS_8; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 371..424
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 426..473
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 633..685
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 686..763
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 765..818
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 864..998
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT COILED 809..836
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 998 AA; 113100 MW; 65BE3F98CC548EAF CRC64;
MNSPSLNWFA KIFIKVPLKT LLIVPFVLQT VVVVTLVGYF SYRSGQEAVE SLADQLITEV
DNRIEQHLNS YLGKAQEINR TNIDAFESGV LDLNDFNALG KYFYRQVRSF NFAYVNFGTK
EGGFIGAGYG LGNKFDIGEI PISDQSKSLS YSVDNQGNRL KLVATLKNPQ YNNAAWYLDA
AKAGKPIWSS IYTWANVPGR ICISASTPVY DQQKGLLGVL GIDLELSHIS EFLKKLDYGK
SGHIFIIERS GLIVASSQGE SSAPTVNGKA TRLQALHSRE PVIRDITQDL IQRFGNLQAI
SKTQLFHPSL SQKLFVRVTP YRDDYGLDWL VVTVIPKSEF MAEIHANAHR TLIICSLSLL
IAVGTGSFTA NWIAKPILRL SRASQAMSKG VWQESLSEDI TIAELKVLAT SFNQMSTQVK
KAFQESETKF STIFHTTPDP VWIATLAEGK FLNVNESFCQ FWGDTPENIL GKTSEQLGLW
KNIENLHHFK ERLINEGSIV NFKLVICTQS QQTKTVLISA KVQYLGEQDC LIGVIRDVSD
LYDELRLRKQ TEIALHKSEA MLLEAQQLAH IGNWDYDVIT GKITWSTQLF QILGRDQTLG
EPTYEEILRL HYPQDAEQLH QAVERSLSTG ESYQLELRVV KADGSFQYTE ARGKAELNAQ
GQVIRLFGTT QDMTERRQIE DQLRASQHFI EQITELTPNL LYIYDHIEQR NVYINRSVAE
ILGYSATAIQ SMGANLFPII CHPDDLYLVY QSMQQLDSLQ DREFVEVEYR VKNAQGQWCW
LYSRDMVFSR TADGRLKQTL GTSQDISKRK KVELALREAE YNLRLANQEL EKLVNIDGLT
QIANRRCFDH RLEQEWQRLY REQEFLSLLL FDVDYFKRYN DAYGHLLGDE CLIKIAQSVQ
QVIFRPADLL ARYGGEEFVV ILPNTDIDGT MVIAQRIHTA IQDLAIPHQA SKVSNIVTIS
IGISSLIPTS ELSPSNLIEQ ADQALYRAKQ QGRNQSVL
//
