ID K7W7Q3_MAIZE Unreviewed; 951 AA.
AC K7W7Q3;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN ORFNames=ZEAMMB73_Zm00001d045603 {ECO:0000313|EMBL:AQL02789.1};
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577 {ECO:0000313|EMBL:AQL02789.1};
RN [1] {ECO:0000313|EMBL:AQL02789.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Seedling {ECO:0000313|EMBL:AQL02789.1};
RG Maize Genome Sequencing Project;
RA Ware D.;
RT "Update maize B73 reference genome by single molecule sequencing
RT technologies.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; CM000785; AQL02789.1; -; Genomic_DNA.
DR AlphaFoldDB; K7W7Q3; -.
DR HOGENOM; CLU_013494_0_0_1; -.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 136..371
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 520..928
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
SQ SEQUENCE 951 AA; 103458 MW; FA86F0C57AB51D4C CRC64;
MISLLQSDIR VALKAAFANM DGPLSVIDWC RGRGNAAESA GTGDAYSFQY SSGDILEPSS
SLSIGGDSMS PPQPTSSNRG ISELEFQKGY HRVRPTIAVL PSPSMLVGYQ DDWLKASVNS
LKTWEKAPFE PYALPKPVTY YALCPDIDML TSAVADFFMQ LGTVYEVCKL GTHSPQNNGG
QMELSPGKYL PSGLVLVDCP EQLKKVRCGH LGPISSTSDC LQAFSKHWSV KSFVTSISRI
LKDIKLTSNI STNQKESSSG PCTVIYVVCP FPEPCAILQT LVECSVALGY VISSPERERK
LLYSQVAKAL NSSASVDEAS ASNVVMLSGF SIPKLVLQIV TIETVLRMDK PNKELAVLKD
IAFTVYNKAR RIPRAVSTSD MFQSPTYLGR SQSTMMHVTS PAPTLWKECL VPRMSGPTLS
RETDFDASMR SATWDNSWQP ARSGGLLDPS KLPDLCAQDD RKYAFEPLFI LADPGSADLN
ALMEPSKSGA DASGSRVYGS ISGSNSDSGV SPLLDVSESD SAASLHCCYG WTEDWRWLVC
IWTDARGELL DSLIFPFGGI SSRQDTKVLQ SLFIQILQQG CQIMSSSPEA SNMRPRDVII
TRIGGFLELE IQEWQKAIYS YGGNEVKKWP VQLRRSIPEG IPPSSNGPTL QQQQQQDMAL
IQDRNMPSSP NPLYSPHPKS SFMKGALGQS GNKKQILVEQ SGMDTSRGSL HLVRSISLVA
VSQDHSLHLT CQADLLSRPA SAGEGSQGSS GPWSYLEGFT PVKSIGSMSA SHSYLLVPSP
SMRYLSPATL QLPTCLTSES PPLAHLLHSK GTAIPLAMGY VVSKAVPPVR RDSAQLTKDE
QPSVLSVSII DHYGGSSGTV QEKMSRGGGG GSKQARNLSQ ETTGRECEME MHSVLEAVAA
ELHSLSWLTV SPVYTERRTA LPFHCDMVLR MRRLLHYADK YLSEPKGETT H
//
