ID K7Z653_9PROT Unreviewed; 4792 AA.
AC K7Z653;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=PtzE {ECO:0000313|EMBL:AFX99653.1};
GN ORFNames=A1OE_1484 {ECO:0000313|EMBL:AFX99653.1};
OS Candidatus Endolissoclinum faulkneri L2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Endolissoclinum.
OX NCBI_TaxID=1193729 {ECO:0000313|EMBL:AFX99653.1, ECO:0000313|Proteomes:UP000010077};
RN [1] {ECO:0000313|EMBL:AFX99653.1, ECO:0000313|Proteomes:UP000010077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2 {ECO:0000313|EMBL:AFX99653.1,
RC ECO:0000313|Proteomes:UP000010077};
RX PubMed=23185008; DOI=10.1073/pnas.1213820109;
RA Kwan J.C., Donia M.S., Han A.W., Hirose E., Haygood M.G., Schmidt E.W.;
RT "Genome streamlining and chemical defense in a coral reef symbiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20655-20660(2012).
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DR EMBL; CP003539; AFX99653.1; -; Genomic_DNA.
DR RefSeq; WP_015089151.1; NC_019566.1.
DR STRING; 1193729.A1OE_1484; -.
DR KEGG; thal:A1OE_1484; -.
DR PATRIC; fig|1193729.4.peg.778; -.
DR eggNOG; COG0236; Bacteria.
DR eggNOG; COG0451; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG2226; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR eggNOG; COG4221; Bacteria.
DR HOGENOM; CLU_223075_0_0_5; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000010077; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 2.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 3.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF08242; Methyltransf_12; 2.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 361..438
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 476..889
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1752..1828
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1867..2290
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3630..4051
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4707..4781
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 4641..4669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4651..4665
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4792 AA; 516360 MW; C3F3605FE19B2E20 CRC64;
MTSYVDPFTI LDRLAKALLF RSATQLGWQP GSVTKFARLE NQRKLAEAID ASLILALNNG
DPALIAAAIL DEQPYLSPHI RLIHHCADAL PNVLSGQITG KEVMFPNGSM DLLANIYAGN
TWADRFNRRV AEAVARAAVA LAAERQGNLR IVEIGAGTGG TTNSILPALD KACRENKLDL
DYAYTDISTE FIEYGRNRFA SVYPFLRFAK MDIEQSPNAQ GFDVNTIDIV VAANVLHATA
QINSTLSHIR DMLTYGGVLI VNEITRSSLF ATMTFGLLDN WWKFKDSGIR QPHSPLLDIA
SWCQSFQLAG LEWPLAIGWE GTVVSDDCQA LLIADRIKND TKVPVQLPNK NDQTRINLSN
SNDNLVRETI TQIVANALGL SIQEIEINRP FAELGVDSIV AGQLATTLTE RLGVAIQASV
LFDHATIAAL AQYAVSLGTR QESLINNSKP MVTSVTEPMV TSVTEPMVTS VTEKKYPDIA
IVGMACRFPK SADLEEFWCN LINGVDCVTE IPDDRFDHMT FSDNEGKKFS HWGGFLDDHD
CFDAEAFRLN PNDATAMSPQ QRVFLECAWH ALEHAGYGQQ ELAGRAVGVY VGVAPDGYGQ
GRSDTRSSLG ESNAILSSRL SYLLDLKGPC LPVDTACSSS LVAIHLAAQT IANGEADMML
AGGVSVFMTS TRLHEFLADS GMSSNSGRCR TFDSEADGFI PGEGVGVVVL KRLDRALAEG
DCIVATLKGS GINHDGRTSG ITAPSGPAQT ELIRAVMARA EVSPADIGYV EAHGTGTKLG
DPIEVNALTR AYGAAEEPCW IGSVKTNIGH TLTTAGVAGF IKAALAVQRG MIPPSLHYRS
DNSELNLTTG RFKVPLKTVN WNSIEGKPRR AAVSSFGFSG TNSHAVVEQA PFRLLPKEAS
GPRPVFFSAR TDSALKEMLE HIAKVLEYAP APFPALAFTL TAGRSHFEHR AGLIASTLDD
LQNGIAKLRE MDPGEIYNNI GRAIVLGAVK ASVSTDPVVA FLSGEEVDLV SLFPAEERLR
VPLPGYPFQR TRLTLPKKQV IIENRSALHP LIVSNISDTT ALRWKLAESS SWPPLRDHRR
NGKPIIAAAV ILEIMQAVAK FAFSDYIVNV ASITFHTPLS FEKLGKATAN LLDDGENWQI
LIVEESTDTI YAKAFLIEPD NYTPDIIDLS DNNNLLGDSR ILNGEAVYAA LADVGFDYGQ
AFRTVERVQV YDNCVIADLK YKAKKEFAWQ PTLIDGAIQS AVGLALGRFT QKQTTIIPIE
IGKAVLFSDL KNARHAIVTE QAQTASDRLV LNIAITDPAG KVLAQLNKIV ALVANAPLRP
KEDAIISFVP RWCPASKALI EPFSKKLLQI INPGQNTLSI LGGDVMETVN DWKLAFQSID
SLPTHVLDLR GLVAINSTPT GQVVDLIAGW LQARPGIPLH ILRVHSENGG IDPDEAGLEG
IAVTLPHEAP EVSLRILSLG RGAGSIADVI REELSISDSE HYVRRFAGER HVRIWEAKSI
EKSDTLPDRP VVLITGASGG IGSIVALHLA RSRNARLVLV GRQGVSNLAK KISSDVIDVA
ADICTIHGAR TAISAAQQKF GRIDVIVHAA GVTGDQLLRN QTSAAISAIM QPKLDGLRYL
LSESNAEPLR TVIGFGSLAA RFGKAGQGGY AAANAAIAAL AERDGLPLRV IDWPFWQTGG
MAGREESDYD LRRTTGSRWI LQEEGLALLD KVMSVPYSRL AIAAGDRELI TAAFTNATVI
NSMPVKAVTS TNSAEDAQKV LKAVLAEVTG IANEFLNPER TIEDLGLDSM HVMTLNEKLE
SQFLGVPPTL FYAHRTIGKV ADFLASLPST ENSKTSQTLT QKSLATQLPN SILSFNRQKN
KGQKTSSEPI AIVGMAGRFP GASNLASFWE LLRDGRNLVT EIPEHRWNVS RYHDDTPGKM
DRSYSRWGGF IEDIDMFDPV HFGIAPADAI RMDPQERLVL EVAAEALEDA ALTRSNLTND
TDRLGSVHIG VMYGDYQLLA ADQHILGNPI AASAPYWSIA NRLSYWLDLH GPSMAVDSAC
SSSLTAIHLA CQSLWSGEVF VAIAGGVNLS IHPLKYIGLS QGRFASTDGL CRSFAEGGDG
YVPGEGVGIV VLKLLSEALN NGDPIHAVIR GSAVTHGGRT NGYTVPSPDA QAKAITTALE
KARVSADQLG FLEAHGTGTA LGDPIELDGI ARATAARTKP LPIGTVKASI GHLEAAAGIA
GLARLVLQFH NNAIAPTILH ASPSKSLKDA SARIRLVTEV EHWPSEQLPR VAGISSFGAG
GANAHLIIEE APIEKTKIQS SAFTEDCIFV FSGRNRVQLE TEIDHFLAIL NKFREPVDLA
RTLQLGRESL FFRIAVLAKN GEELSTKLSA WRKGDPAKDV FFGNADGGGK YITSDSLKLK
EIAQAWTTGA SIDWSKLPLS GKRIRIPPRP LLRQRFWPNL LEAPVIKSIP VSDAELHLTV
ENPILRDHKF QHLPLLPAAA SLAVMSNCAE CILQDIAFLL PGWANENGLQ LKRQIMNGKV
KILSQGLIIA SGVLISTAET ILNSISAPVV NTSYTTQSEN IIYDRFRMLG IDYGATFRRL
TELHSDGNTT EAHLKPLINA DAMTRQVSDI DATFQAIGPL RWDDIDKPGV PVAINSMALF
GQSNSAVTVR AKRISDSLFD AEALDAKGNT VIQIKGLRVE KMPIPEQEVD DIAPRLLTPV
WLQRSLIENH RQSDQLGRVV LIRMNDETQF LKRLVDRVAP IANLTFAETL HGIPDCDSMI
LVTNLAISSH SWSIKQAVDA TAIIESVGNL ARTVAASNKP PKQILLVTAG IFDIDGKQTF
NPINAGIVGL LRSLVAELPS TGLVLLDLET TSIDTPQAID RLLQEPIQQG GVRVAWRGEN
RYIEALSDTT LSNDCSSSVN TKMPLVCLIT GGSGGIGLAL AQYLLATKNA IVVLSGRREH
PAITLPEGVR YQVADVTDYA ALTTLCDDIV RIHGRLDIVF HLPLVLNDSK LASMSAVEFS
APLGPKAVGT ANVLAVAQLA GAKLAVIFSS ANVFAGVAGQ ANYVAASCMQ DAIALSFNGN
MRVQVINWGL WGEIGAVADL ATQAKLRRGG IYPIAPKDAF QVLDNILESG VQRVAVVAAE
SKALSRLGWR DKADLGTDLG KDIVAFRRLE AYGYTRLATS LVNSLNLQAD QPLTANTLAG
KLQIIERFKP LFSAIVEMLC RAGLASKHKD LISLPRLGLN LAKQKQITED AISNNMPDWI
SGPRIILDAV LDVYPDLLSG SINPLSILFP GGKSNLIAAA YHGNPISDNF NAATASAMIS
ALSPGAAIIE IGAGTGGGTA AAIAALDNYN PAKSYLFTDI SKQFLDAASK NFNSLRRPWF
KTALYDIEQT VEANSQIPGS ADIVLATNVL HAVADLPKVL RELGRLLKPN GTLIVNELIE
VQDFATMVFG LTDGWWRGFG SAERLPYSPI IDSNGWHTLL ETEGYRNIRL NDLSARGGRG
QAVIIANAPS GVRLVAGKEV VNKINQFEPQ GDQTDPIKDG LLQALIDDLR SIIANQLAID
PAELRANQSL GEYGLESLSS MAVRDVLDAK FGGVSQTLMF EHDTLTGLAN HLISVRPTEV
RAVLQNTKNI NSIDKNKIKQ SNSKQIMPVN TPIAVIGIAG RFPGADTPNA LWQLVENGLS
ALGPVPEGRW KSNNWYDPSG GEGLSYTKIG GFLPDIDCFD PLYFGISPID AENLDPQERL
FLQTAWHALE NAGSTPARLQ RRAGPVGVFV GVMNAGYQWL SAQNNKAPAT SSYWSIANRL
SYVADWTGPS LAVDTACSSS LTALHLAVNA LRDGQCGAAV VGGVNLIVHP RQLANLSEAR
MLSPSGECRS FGEGADGFVD GEGIVALVIK PLNTALRDND RIEAIIRGTA INAGGRTSSF
SVPSPVAQSK VATDALANAG VDPITIQVVE THGTGTSIGD PIEASGLSIA YKGEGRRVNP
LIIGALKANI GHLESAAGIA GIVKAIFQLR YQKIAPLRDA MTLNPRIDLE ALALYAPPQA
IEWPAPENCP RRIAVSSFGA GGANAHVVLE EAPPMINVEA SNLNSELFVL STVDADRQKH
LSSVLHDFIS EQGYRQNDIT RICHTLRVGR RALSYRFAMP IRNINDLLNA LNKLAIGQMP
KGGINGNGSG ETIRILEESS SGQALLREKL AARDIDALAR LWVDGADIDW DELPETNRIV
PIELPGTIFA KEKYWLAEPV FTNVNTKIDM PVRFIKRSWK QTALLSPSNS TPSCLFVYDS
NSISINQSSN ELKLPDNRMG WDQLLNRMPI GSASDLVLIV NKVTNIRELH CVTLATLIGL
SVIMARPGRL KRVFLTTSSE TLATVFAAIA ASVSLEGLNG RVRTILLPKE DFTEIIESER
TIDMSGAPLV DRRGARAIAI RQTIDMSIEC NLMIGPGSRV LLVGGLGEVG TALIKVLINK
RKARVGVIGR REINNTLLTK LNISYAVADI TDEDNLSAAI GKIRSLIGGI DFVIDLARIV
DDSTLASKDD VQIESVLAVK TLGTDLLDRV TRNDHLKAFI VFSSLASWFG LPGAADYAAA
CAFQDALMNI RSGPGLSLSI AWPQWEYDSK LTPTRQGELE KSGLGTINAE KGLDLIDQAL
ASKENILAVA TGRLDVIEGL TSPTDVSDPD VSDPDVSDPD VSDPDVSDPD ISLMNDSQLE
FYVKRLRSEA RLISRPKALA SNPISIPSSD ISIKAALVKH LKVDHALLKS DTSFVDLGID
SIKALHIAET LATTLSIEVE PALLASHPTV EELAKVLDQR KAETISCATD NN
//
