ID K7ZD72_9PROT Unreviewed; 101 AA.
AC K7ZD72;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase {ECO:0000256|HAMAP-Rule:MF_00434};
DE Short=PHS {ECO:0000256|HAMAP-Rule:MF_00434};
DE EC=4.2.1.96 {ECO:0000256|HAMAP-Rule:MF_00434};
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase {ECO:0000256|HAMAP-Rule:MF_00434};
DE AltName: Full=Pterin carbinolamine dehydratase {ECO:0000256|HAMAP-Rule:MF_00434};
DE Short=PCD {ECO:0000256|HAMAP-Rule:MF_00434};
GN Name=pcbd2 {ECO:0000313|EMBL:AFX99256.1};
GN ORFNames=A1OE_1078 {ECO:0000313|EMBL:AFX99256.1};
OS Candidatus Endolissoclinum faulkneri L2.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Rhodospirillaceae; Endolissoclinum.
OX NCBI_TaxID=1193729 {ECO:0000313|EMBL:AFX99256.1, ECO:0000313|Proteomes:UP000010077};
RN [1] {ECO:0000313|EMBL:AFX99256.1, ECO:0000313|Proteomes:UP000010077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L2 {ECO:0000313|EMBL:AFX99256.1,
RC ECO:0000313|Proteomes:UP000010077};
RX PubMed=23185008; DOI=10.1073/pnas.1213820109;
RA Kwan J.C., Donia M.S., Han A.W., Hirose E., Haygood M.G., Schmidt E.W.;
RT "Genome streamlining and chemical defense in a coral reef symbiosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20655-20660(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554, ECO:0000256|HAMAP-
CC Rule:MF_00434};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472, ECO:0000256|HAMAP-
CC Rule:MF_00434}.
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DR EMBL; CP003539; AFX99256.1; -; Genomic_DNA.
DR RefSeq; WP_015088754.1; NC_019566.1.
DR AlphaFoldDB; K7ZD72; -.
DR STRING; 1193729.A1OE_1078; -.
DR KEGG; thal:A1OE_1078; -.
DR PATRIC; fig|1193729.4.peg.589; -.
DR eggNOG; COG2154; Bacteria.
DR HOGENOM; CLU_081974_3_2_5; -.
DR OrthoDB; 9794987at2; -.
DR Proteomes; UP000010077; Chromosome.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR HAMAP; MF_00434; Pterin_4_alpha; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR PANTHER; PTHR12599:SF0; PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00434}.
SQ SEQUENCE 101 AA; 11496 MW; 9E1A5B67CF410D2D CRC64;
MVEKLSIKEL NNNLVSMDGW TKTNDNTAII KTFNFKSFDD AWNFMTQVAI KSSSMNHHPD
WSNSYNKVIV ELSTHNIGGV TDLDIELANY MDVTALDIRL I
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