ID K7ZPW2_FELCA Unreviewed; 608 AA.
AC K7ZPW2; M3W8U4;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Tripartite motif 25 {ECO:0000313|EMBL:BAM66374.1};
DE SubName: Full=Tripartite motif containing 25 {ECO:0000313|Ensembl:ENSFCAP00000007439.3};
GN Name=TRIM25 {ECO:0000313|EMBL:BAM66374.1,
GN ECO:0000313|Ensembl:ENSFCAP00000007439.3,
GN ECO:0000313|VGNC:VGNC:66531};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|EMBL:BAM66374.1};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000007439.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007439.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000007439.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007439.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BAM66374.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23497841; DOI=10.1016/j.vetimm.2013.02.009;
RA Koba R., Kokaji C., Fujisaki G., Oguma K., Sentsui H.;
RT "Characterization of feline TRIM genes: molecular cloning, expression in
RT tissues, and response to type I interferon.";
RL Vet. Immunol. Immunopathol. 153:91-98(2013).
RN [4] {ECO:0000313|Ensembl:ENSFCAP00000007439.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000007439.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB734707; BAM66374.1; -; mRNA.
DR RefSeq; NP_001277180.1; NM_001290251.1.
DR STRING; 9685.ENSFCAP00000007439; -.
DR PaxDb; 9685-ENSFCAP00000007439; -.
DR Ensembl; ENSFCAT00000008032.5; ENSFCAP00000007439.3; ENSFCAG00000008031.5.
DR GeneID; 101084663; -.
DR KEGG; fca:101084663; -.
DR CTD; 7706; -.
DR VGNC; VGNC:66531; TRIM25.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160741; -.
DR OMA; KRGVHYW; -.
DR OrthoDB; 5359093at2759; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000008031; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0039552; F:RIG-I binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0002753; P:cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0036503; P:ERAD pathway; IEA:Ensembl.
DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR GO; GO:0044790; P:suppression of viral release by host; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0019076; P:viral release from host cell; IEA:Ensembl.
DR CDD; cd19842; Bbox1_TRIM25-like_C-IV; 1.
DR CDD; cd19776; Bbox2_TRIM25_C-IV; 1.
DR CDD; cd16597; RING-HC_TRIM25_C-IV; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF40; E3 UBIQUITIN_ISG15 LIGASE TRIM25; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 13..54
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 417..608
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 355..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 608 AA; 68623 MW; 9531D609CFCC5EFF CRC64;
MAELVPLAEE LSCSICLEHF KVPVTTPCGH NFCSSCLDET WAVQEPPYLC PQCRASYQER
PQLHKNTVLC AVVEQFLQAE VARVAPSPPD GCTPPARAAE PSPPCQVACD HCLKAPAVKT
CLVCMASFCQ EHLQPHLDSP AFRDHQLQPP VKDLMRRKCP QHNRLRDFFC PQHDECICHI
CLVEHKACSP ETLSQASADL QTKLKHKLTI ICDQINGASR ALEDVRARQQ DIRETARRKT
EQLRQEYVEI KILIDAAEAI CTRKIKEEQK RVSTKFDNIY QILLKNKSEI QTLKEEIELA
LTKEDEFEFL EKAIKLQGIS TKPVYVPKME LNQELIKGVC QGTSDLKNEL KRYIRLPQDK
KPEGPAGSGN LGEHGPASTH KPAHFVKKVL KEEKKHKKPP VAKASAVQPN PVSLTTKVLD
TFLAKSRPEL LEYATKFSLD YNTAHNKVAL LENYTVASVA DLPLNYQPHP KRFTYCSQVL
GLHYYRKGIH YWEVELQKNN FCGVGICYGS MPRQGPDSRL GRNSASWCVE WFNTKVSAWH
NNVEKTLPST KATRVGVLLN CDHGFVIFFA VTDNVHLMCK FKVDFTEAVY PAFWVFSAGA
TLSICSCK
//
