ID   K8CNQ5_CROSK            Unreviewed;       684 AA.
AC   K8CNQ5;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=BN128_299 {ECO:0000313|EMBL:CCK06488.1};
OS   Cronobacter sakazakii 696.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=1208664 {ECO:0000313|EMBL:CCK06488.1, ECO:0000313|Proteomes:UP000009356};
RN   [1] {ECO:0000313|EMBL:CCK06488.1, ECO:0000313|Proteomes:UP000009356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=696 {ECO:0000313|EMBL:CCK06488.1,
RC   ECO:0000313|Proteomes:UP000009356};
RX   PubMed=23166675; DOI=10.1371/journal.pone.0049455;
RA   Joseph S., Desai P., Ji Y., Cummings C.A., Shih R., Degoricija L., Rico A.,
RA   Brzoska P., Hamby S.E., Masood N., Hariri S., Sonbol H., Chuzhanova N.,
RA   McClelland M., Furtado M.R., Forsythe S.J.;
RT   "Comparative analysis of genome sequences covering the seven cronobacter
RT   species.";
RL   PLoS ONE 7:e49455-e49455(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCK06488.1}.
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DR   EMBL; CALF01000071; CCK06488.1; -; Genomic_DNA.
DR   AlphaFoldDB; K8CNQ5; -.
DR   Proteomes; UP000009356; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR022161; Helicase_IV_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12462; Helicase_IV_N; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          195..505
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         216..223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   684 AA;  77660 MW;  1230B34E4BC42EC3 CRC64;
     MELKATSLGK RLAQHPYDRA EILTAGVKVS GDKHEYLIPF NQLLGIECRR GLVWGELEFT
     LPDNKVVRLH GTEWAETQRF YHHLMALWQQ WSQEMSEVAA GVLNAWQEKL RSSESQEKWL
     KREEGEALCH ALRRALQALP MPISRLEAFD NCREAWRECQ AWLADSEAKR LLHNQAYTDA
     MLTRYADFFS QIESSPLNPS QARAVVNGES SLLVLAGAGS GKTSVLVARA GWLIERGEAT
     AEQILLLTFG RQAAKEMEER LQARLHTDAI TARTFHALAL QIIGQGGRKT PRVSELENDT
     AARHELLLNA WREQCREKKA QAKGWRQWLT DELEWDVEDG DFWEDETLGK RLASRLDRWL
     GLMRMHGGSQ TEMIAAAPDE VRDLFQKRVK LMAPLLKAWK AALKAEEAVD FSGLIHQAIN
     VLEKGRFVSP WKHILVDEFQ DISPQRAALL AALRRQNSAT SLFAVGDDWQ AIYRFSGAQL
     SLTTAFEAHF GRGDQCALDT TYRFNGRIGD IANRFIQQNP HQREKPLNSL RAGDKNAVTL
     LAQEQLEALL DKMSGYVRPD ERILVLARYH HLRPAALEMA ATRWPKLQLE FMTIHASKGQ
     QADYVIILGL NEGREGFPAP ARESIMEQAL LPPPEDFPDA EERRLLYVAL TRARHRVWLL
     YDKAAPSVFV EALTRLGVPT ARKP
//