ID K8D5M3_CROSK Unreviewed; 525 AA.
AC K8D5M3;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Penicillin-binding protein 2 (PBP-2) {ECO:0000313|EMBL:CCK06015.1};
GN ORFNames=BN128_4334 {ECO:0000313|EMBL:CCK06015.1};
OS Cronobacter sakazakii 696.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Cronobacter.
OX NCBI_TaxID=1208664 {ECO:0000313|EMBL:CCK06015.1, ECO:0000313|Proteomes:UP000009356};
RN [1] {ECO:0000313|EMBL:CCK06015.1, ECO:0000313|Proteomes:UP000009356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=696 {ECO:0000313|EMBL:CCK06015.1,
RC ECO:0000313|Proteomes:UP000009356};
RX PubMed=23166675; DOI=10.1371/journal.pone.0049455;
RA Joseph S., Desai P., Ji Y., Cummings C.A., Shih R., Degoricija L., Rico A.,
RA Brzoska P., Hamby S.E., Masood N., Hariri S., Sonbol H., Chuzhanova N.,
RA McClelland M., Furtado M.R., Forsythe S.J.;
RT "Comparative analysis of genome sequences covering the seven cronobacter
RT species.";
RL PLoS ONE 7:e49455-e49455(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCK06015.1}.
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DR EMBL; CALF01000071; CCK06015.1; -; Genomic_DNA.
DR AlphaFoldDB; K8D5M3; -.
DR Proteomes; UP000009356; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022645}.
FT DOMAIN 20..131
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 164..500
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 525 AA; 58588 MW; B5F74DB534B8710F CRC64;
MQDTLEALRS VVDLNDDDIR FTSIPVKTNL TEVQVARFAV NQYRFPGVEV KGYKRRYYPY
GAALTHVIGY VSKINDKDVE RLDKDGKLAN YAATHDIGKL GIERYYEDVL HGQTGYEEVE
VNNRGRVIRQ LKEVPPQAGH DIYLTLDLKL QTYIETLLQG SRAAVVVTDP RTGGILAMVS
MPSYNPNLFV DGISSKDYSG LLNDPNTPLI NRATQGVYPP ASTVKPYVAV SALSAGVINR
NTSLFDPGWW QLPGSEKRYR DWKKWGHGRL NVTKSLEESA DTFFYQVAYD MGIDRLSEWM
RKFGYGSLTG IDLSEERSGN MPTREWKMKR FKKPWYQGDT IPVGIGQGYW TATPVQMNKA
MMILINDGVV KVPHLLMTTV VNGQKVPWKQ PEQPPVGDIH SGYWEIAKDG MYGVANRANG
TGHKYFAGAP YKIAAKSGTA QVFGLKANET YNAHRIAERL RDHKLMTAFA PYDNPQVAVA
MILENGGAGP AVGTIMRQIL DHIMLGDNNT ELPTENPATA AAEDR
//
