ID K8E0U5_9FIRM Unreviewed; 690 AA.
AC K8E0U5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:CCO09180.1};
GN ORFNames=DESHY_60352 {ECO:0000313|EMBL:CCO09180.1};
OS Desulforamulus hydrothermalis Lam5 = DSM 18033.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulforamulus.
OX NCBI_TaxID=1121428 {ECO:0000313|EMBL:CCO09180.1, ECO:0000313|Proteomes:UP000009315};
RN [1] {ECO:0000313|EMBL:CCO09180.1, ECO:0000313|Proteomes:UP000009315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lam5 / DSM 18033 {ECO:0000313|Proteomes:UP000009315};
RX PubMed=23405336; DOI=10.1128/genomeA.00114-12;
RA Amin O., Fardeau M.L., Valette O., Hirschler-Rea A., Barbe V., Medigue C.,
RA Vacherie B., Ollivier B., Bertin P.N., Dolla A.;
RT "Genome Sequence of the Sulfate-Reducing Bacterium Desulfotomaculum
RT hydrothermale Lam5(T).";
RL Genome Announc. 1:e00114-e00112(2013).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCO09180.1}.
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DR EMBL; CAOS01000013; CCO09180.1; -; Genomic_DNA.
DR RefSeq; WP_008413050.1; NZ_FQXF01000012.1.
DR AlphaFoldDB; K8E0U5; -.
DR STRING; 1121428.DESHY_60352; -.
DR eggNOG; COG1298; Bacteria.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000009315; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:CCO09180.1};
KW Cilium {ECO:0000313|EMBL:CCO09180.1};
KW Flagellum {ECO:0000313|EMBL:CCO09180.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000009315};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 17..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 41..60
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 104..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 281..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 690 AA; 75525 MW; FFDA5D4535B40897 CRC64;
MAAPSTLAAN LKQYSDLVIA GLIIGIVLLI IVPLPPGMLD FFLILSMSLG LVIMLITMFT
TEPLQFSIFP SLLLVTTLYR LALNISSTRL ILGEGAAGKV IEAFGQFVVG GNYVVGAVVF
IIITVIQFVV ITNGSGRVAE VGARFTLDAM PGKQMSIDAD LNSGLITEDE ARAKRERLQR
EADFFGAMDG ASKFVRGDAI AGIVILIINI LGGFVIGVVQ LGLPMEEALK RFTILTIGDG
LVAQIPALLI STAAGILVTR ATSEGTFGKD IAKQFLNFPR VLLLAGVILG FIGLIPAMPN
LLFLSMAAVL LYAAKTVSRE RTRQALAEQQ AQALQAQKMQ KREPENVFSY FQVDPLEIEI
GYNLIALTDE SQGGDLLQRL AAVRRQCAAE MGILVRPIRI RDNMQLSYNA YVIKIRGVEV
ASGELMPGHH LAMDPLGQEL QFNGIPTTEP TFNLPAWWVA GADRELVELH GFTVVDCSTV
LVTHLTEILK QHAHELLGRQ EVKELIEVVK EKNPAVVEEL VPDMLSLGEI QKVLQNLLKE
RVPIRDLVTV LEALADGARI NKDPDYLTDC ARQSLSRTIC QRYTDDRGKL SVITLHPRLE
QAVQEAIQPT QFGAYPVLEP QLVRKLLDKL NTVVEDVTMR GLNPVVLCSP RVRLPFRRLI
ERYLPNLAVL SLNEIPANLD VEAIGTVSID
//
