ID K8EIN0_9FIRM Unreviewed; 504 AA.
AC K8EIN0;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=NADH dehydrogenase subunit M {ECO:0000313|EMBL:CCO08461.1};
DE EC=1.6.5.3 {ECO:0000313|EMBL:CCO08461.1};
GN ORFNames=DESHY_40011 {ECO:0000313|EMBL:CCO08461.1};
OS Desulforamulus hydrothermalis Lam5 = DSM 18033.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulforamulus.
OX NCBI_TaxID=1121428 {ECO:0000313|EMBL:CCO08461.1, ECO:0000313|Proteomes:UP000009315};
RN [1] {ECO:0000313|EMBL:CCO08461.1, ECO:0000313|Proteomes:UP000009315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lam5 / DSM 18033 {ECO:0000313|Proteomes:UP000009315};
RX PubMed=23405336; DOI=10.1128/genomeA.00114-12;
RA Amin O., Fardeau M.L., Valette O., Hirschler-Rea A., Barbe V., Medigue C.,
RA Vacherie B., Ollivier B., Bertin P.N., Dolla A.;
RT "Genome Sequence of the Sulfate-Reducing Bacterium Desulfotomaculum
RT hydrothermale Lam5(T).";
RL Genome Announc. 1:e00114-e00112(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCO08461.1}.
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DR EMBL; CAOS01000011; CCO08461.1; -; Genomic_DNA.
DR RefSeq; WP_008411903.1; NZ_FQXF01000019.1.
DR AlphaFoldDB; K8EIN0; -.
DR STRING; 1121428.DESHY_40011; -.
DR eggNOG; COG1008; Bacteria.
DR OrthoDB; 9807568at2; -.
DR Proteomes; UP000009315; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR NCBIfam; TIGR01972; NDH_I_M; 1.
DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR PANTHER; PTHR43507:SF4; PROTON-TRANSLOCATING NADH-QUINONE OXIDOREDUCTASE, CHAIN M; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:CCO08461.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009315};
KW Transmembrane {ECO:0000256|RuleBase:RU000320, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..428
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 504 AA; 54339 MW; 29F57DEE487F4B6F CRC64;
MNMPILTLTL LAPVLAALII VFIPKEEEKL CKWVAAFGTG LALLLSLYVY FGYDRTVGGL
QWVDFGGPVP WIKDLGVSYY MAVDGLSLPM LLLTNLIGFA AVFASWNVTH RAKELMIYLL
ILIAGVMGTF IAQDLFIFLL FYEVVVIPIY IMVIIWGSSK RVTKEYAGMK LTIYLLIGSA
FLLVGVIATF VHSVAITGTP DMSFEGLARV ALPEQFQIYM FGLMLLGFGS LLSMWPFHSW
SPDGYAGAPT AVSMIHAGVL KKIGGYGLIR IAIFVLPLGA KFWAPWIAVL GVIGVAYAAL
GALAQKDLKY VVGYSSVSHM GYVLLGVASL GVVGVNGAVA NMFAHGVMAA LFFSMIGFIY
EKTHTRWIPD LGGLSHQAPR LSVGFMMAAM ASLGLPGLIS FIPEFTIFVE SFRVFGWLAV
VAIAGIIITA LYVLRAGANT LFGPAREEYN HIKDIRGPEL VPLVVLGGVL VIGGILPSLL
FDMVNSGVTP ILAHIQEALQ IGGK
//
