ID   K8EKX7_CARML            Unreviewed;       462 AA.
AC   K8EKX7;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 2.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE            EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE   AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN   Name=menF {ECO:0000313|EMBL:CCO12523.2};
GN   ORFNames=BN424_3102 {ECO:0000313|EMBL:CCO12523.2};
OS   Carnobacterium maltaromaticum LMA28.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Carnobacterium.
OX   NCBI_TaxID=1234679 {ECO:0000313|EMBL:CCO12523.2, ECO:0000313|Proteomes:UP000000212};
RN   [1] {ECO:0000313|Proteomes:UP000000212}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=LMA28 {ECO:0000313|Proteomes:UP000000212};
RX   PubMed=23405327; DOI=10.1128/genomeA.00115-12;
RA   Cailliez-Grimal C., Chaillou S., Anba-Mondoloni J., Loux V., Afzal M.I.,
RA   Rahman A., Kergourlay G., Champomier-Verges M.C., Zagorec M., Dalgaard P.,
RA   Leisner J.J., Prevost H., Revol-Junelles A.M., Borges F.;
RT   "Complete Chromosome Sequence of Carnobacterium maltaromaticum LMA 28.";
RL   Genome Announc. 1:0-0(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC         ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000799};
CC   -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC       {ECO:0000256|ARBA:ARBA00005297}.
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DR   EMBL; HE999757; CCO12523.2; -; Genomic_DNA.
DR   RefSeq; WP_016356641.1; NC_019425.2.
DR   AlphaFoldDB; K8EKX7; -.
DR   STRING; 1234679.BN424_3102; -.
DR   KEGG; cml:BN424_3102; -.
DR   eggNOG; COG1169; Bacteria.
DR   HOGENOM; CLU_006493_8_4_9; -.
DR   OrthoDB; 9803598at2; -.
DR   Proteomes; UP000000212; Chromosome.
DR   GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR015890; Chorismate_C.
DR   InterPro; IPR004561; IsoChor_synthase.
DR   NCBIfam; TIGR00543; isochor_syn; 1.
DR   PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR   PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   SUPFAM; SSF56322; ADC synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CCO12523.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000212}.
FT   DOMAIN          195..448
FT                   /note="Chorismate-utilising enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00425"
SQ   SEQUENCE   462 AA;  51090 MW;  E7F995EBC46FAC7E CRC64;
     MWTLPSDISE AAKLKLEEHS SVLVSYVREL NELDALTLFK KGAKKYTGQR IFWQNPSKTV
     TLAGIGCTER YSSKAGNESY TELNQFKDKL KKQTVSNEII LGTGALLIGG FSFDSLAKAD
     ANWEEFQDAY FSLPTYLLTT TAEKSYITFN FYVTQADLIE KPLRIMKQWE ELLATPFVTE
     TEIAAITKKE ELATDSWLAA VSETVDAIKA SKELNKVVLS RQMLLTHETD VAIEAVLEKL
     KKTQQNSYFF VVENGEKTFL GATPERLLSA EGNKFYSACV AGSAKRGATF AEDQAIGDRL
     LADHKNVHEH QLVVEMIRHT MEGFTTDLAI SGGPTLLKNR DIQHLFLTLA GTKKEHFSFL
     EAVKGMHPTP ALGGVPTDLA LEVIRQKEPY NRGFYGAPIG WVDSSDQGEF AVGIRSALIM
     GQQSLLFAGC GIVAGSDPTE ELNETAIKFQ PMLRALGGME NE
//