ID K8ESI6_CAEEL Unreviewed; 1056 AA.
AC K8ESI6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Rab-GAP TBC domain-containing protein {ECO:0000313|EMBL:CCO25630.1};
GN Name=tbc-9 {ECO:0000313|EMBL:CCO25630.1,
GN ECO:0000313|WormBase:Y45F10A.6f};
GN ORFNames=CELE_Y45F10A.6 {ECO:0000313|EMBL:CCO25630.1}, Y45F10A.6
GN {ECO:0000313|WormBase:Y45F10A.6f};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCO25630.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCO25630.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCO25630.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CCO25630.1; -; Genomic_DNA.
DR RefSeq; NP_001263808.1; NM_001276879.1.
DR AlphaFoldDB; K8ESI6; -.
DR SMR; K8ESI6; -.
DR EnsemblMetazoa; Y45F10A.6f.1; Y45F10A.6f.1; WBGene00012868.
DR GeneID; 178316; -.
DR AGR; WB:WBGene00012868; -.
DR WormBase; Y45F10A.6f; CE47998; WBGene00012868; tbc-9.
DR OrthoDB; 3034081at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00012868; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; K8ESI6; baseline and differential.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR CDD; cd13354; PH-GRAM2_TCB1D9_TCB1D9B; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.10.750; Ypt/Rab-GAP domain of gyp1p, domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR036017; TCB1D9/TCB1D9B_PH-GRAM2.
DR PANTHER; PTHR47219:SF9; GTPASE ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR47219; RAB GTPASE-ACTIVATING PROTEIN 1-LIKE; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Proteomics identification {ECO:0007829|EPD:K8ESI6,
KW ECO:0007829|PeptideAtlas:K8ESI6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 300..487
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 227..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 120187 MW; FCBF5344676765DB CRC64;
MGNETKIKLK WTDIVRLERV SSILFPQSIL VVTKEDKKFS FSMFLNFEET FQLASQLANI
AMKQLIEEEG FCEDSALRRK MLMESEHRRT VKTKASFLKR DLDARHRSDA FRCQFNLPLT
EKLDGDTQCR LFTPYDRRHV PGKLFVSANF VCFASRTERL VSIVVPLIEV TSIEECSPVS
SSQTTQGILL CLRNDATVIF SAVPDRDRVL SKITVFLERG KIERTMEKAK ADSERGRSST
SSSSSSFDKL IWDCPLIEKY PFGADASDKC REKWNKYLQE YGTGVCMYRT VELHRLLLEG
VPLQLRGQIW MVCSGAAAEM ALNPGYYREL LHKNQGVYSV ALEEIERDLH RSLPEHPAFQ
QGPGIDALRR ILTAYAFRNP NIGYCQAMNI VGSVLLLFTK EEEAFWLLVA VCERLLPDYY
NTKVVGALVD QGVFSELVER LLPTVGAQLT RLGLDDMVAL SWFLTVFLSA IKFDAAVRIL
DLFFFEGARL MFQVALEMLK ENEKLICESR DDGEILMSLA KYTESIYEGD TVVERKPSTV
QLGTTILSDL EEAASTMINF MGTDITRTFP KIPIGDLLAN SYQNFGYCFT NENIETLRLK
NRLKVVQNLE DNQMRSIIKS IGKDCRFTNE ELEALYNVVK EEHLLSWRHR LGVSARGKMA
AVTERPRPDP CAQSQYRLDY DLFSEVFPRL LPWPVTNIFI IRVFRLLDIS DNGLLTFRDL
AINLSILLRG EATEKLALFY KCHLPPAFNM SDLDGLDSSE ESSPERKDGE PELAIEATDL
LGTPKRTQAQ LQERRSNSVD IPRKESDQNL ADSLRTRCST SSAVMIHANM EERASDAESL
IDLIASKSIG SCPSETDVDR IQVADVAKSY SVVDESIEKM KQLRAKALSS PDSSSTKLEM
KMLPVMSQIQ FIQLWKTFYD MLSGKETEQS VFHSLAVTGT LLLQLGETHR ELQAKLEAQI
ADAMQDLDET LKHVEDGDEE FEEDRKIDPI EVQRKRIGDM QTCFSMADDE WRVNLEQILA
SVMAETTLAD FFERKYSLDA LIKKYYKTRF STDSIN
//