ID K8GQI1_9CYAN Unreviewed; 546 AA.
AC K8GQI1;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=NhaP-type Na+(K+)/H+ antiporter {ECO:0000313|EMBL:EKQ69726.1};
GN ORFNames=OsccyDRAFT_2369 {ECO:0000313|EMBL:EKQ69726.1};
OS Leptolyngbyaceae cyanobacterium JSC-12.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Leptolyngbyales; Leptolyngbyaceae.
OX NCBI_TaxID=864702 {ECO:0000313|EMBL:EKQ69726.1, ECO:0000313|Proteomes:UP000001332};
RN [1] {ECO:0000313|EMBL:EKQ69726.1, ECO:0000313|Proteomes:UP000001332}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JSC-12 {ECO:0000313|EMBL:EKQ69726.1,
RC ECO:0000313|Proteomes:UP000001332};
RG DOE Joint Genome Institute;
RA Brown I., Huntemann M., Wei C.-L., Han J., Detter J.C., Han C., Tapia R.,
RA Chen A., Kyrpides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L.,
RA Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RT "Improved high quality draft of Oscillatoriales sp. JSC-12.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the universal stress protein A family.
CC {ECO:0000256|ARBA:ARBA00008791}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKQ69726.1}.
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DR EMBL; AJUB01000010; EKQ69726.1; -; Genomic_DNA.
DR AlphaFoldDB; K8GQI1; -.
DR STRING; 864702.OsccyDRAFT_2369; -.
DR PATRIC; fig|864702.5.peg.2547; -.
DR eggNOG; COG0025; Bacteria.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_018415_1_0_3; -.
DR OrthoDB; 9790604at2; -.
DR Proteomes; UP000001332; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR CDD; cd00293; USP_Like; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006015; Universal_stress_UspA.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR31102; -; 1.
DR PANTHER; PTHR31102:SF1; NA_H_EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR01438; UNVRSLSTRESS.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001332};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..389
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 420..536
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 546 AA; 57788 MW; EA019ABD2B614A60 CRC64;
MLESIIWILL MGFFVGQIAR RLKAPALVGM VLVGIVLGPQ VGDLISREVL EAANALRTIA
VMVILMKAGL GLDREKLSQQ GSVALRLGFL PAACEAIAIA LAAMWLFQFD FATGLLLGCV
IGAESPAVIV PGMLRLKSLG WGVEKGIPDA ILTGSALSDV LLLLVFSLLL AFLTQGAATG
VTLPGGLTLS PVQLLPFQII LQISLGVAIG WLTAYLLVSL LARQNWTQSA VQDALVTAGC
ALLLVVLAED FPIFSGYLAV MATGFFLIEL DAPLARRLRG GFDSLWAIAE IFLFVLLGAS
IELQELGGIL LVGLLILAIG TLLGRSLGWY LSTIGSNWNW KERLFLLPGN SAKATVQAAI
GAIPLAQGIT GGKTILALSA LSILVTAPLG AWAIPTFAPK LLQRGEVDPT KVAVSRRIVL
LAAVDTSPLA VQVLTKAAEL ARRSDAEVVV LSVIRVDEPG AVEWLRDQVN QLLADIRHRF
ITTSGSVPEE IVQTAQTYGV AEIVMGKRGH RPLEEVLVGS VSQAVLETSP FPVVIVEADP
SPFTVH
//
