ID K8NWM6_9BRAD Unreviewed; 363 AA.
AC K8NWM6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=HMPREF9695_04632 {ECO:0000313|EMBL:EKS34722.1};
OS Afipia broomeae ATCC 49717.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Afipia.
OX NCBI_TaxID=883078 {ECO:0000313|EMBL:EKS34722.1, ECO:0000313|Proteomes:UP000001096};
RN [1] {ECO:0000313|EMBL:EKS34722.1, ECO:0000313|Proteomes:UP000001096}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49717 {ECO:0000313|EMBL:EKS34722.1,
RC ECO:0000313|Proteomes:UP000001096};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Afipia broomeae ATCC 49717.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKS34722.1}.
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DR EMBL; AGWX01000005; EKS34722.1; -; Genomic_DNA.
DR RefSeq; WP_006023336.1; NZ_KB375284.1.
DR AlphaFoldDB; K8NWM6; -.
DR PATRIC; fig|883078.3.peg.4784; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_5; -.
DR Proteomes; UP000001096; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001096};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 125..347
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 363 AA; 39108 MW; 565B8152DB8F6D4E CRC64;
MAHHDPIGHL ITPNAGLAQL NERSRDIFRQ IVESYLATGE PVGSRNISRL ITMPLSPASV
RNVMSDLEQL GLIYAPHTSA GRLPTELGLR FFVDALMQVG DLTEPERQSI ESQLKSVGGA
TSVEAALSEA LTRLSGLTRA AAVVLTQKSN VRLKHIEFVR LEPTQALVVL VAEDGQVENR
VLTLQPGVPS SALTEASNFL NARIRGRTLA EARSELEAAL TAGRSELDQL TQKVIAAGIA
SWSGGASDER QLIVRGHANL LEDLHAMEDL ERVRLLFDDL EAKKGVIDLL GRAERADGVR
IFIGSENKLF SLSGSSTIIA PYRDGAGHIV GVLGVIGPTR LNYARVIPTV DYAARIVSQL
IGK
//
