ID K8WPR0_9GAMM Unreviewed; 393 AA.
AC K8WPR0;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Multidrug efflux system protein EmrA {ECO:0000313|EMBL:EKT59452.1};
GN ORFNames=OO7_05704 {ECO:0000313|EMBL:EKT59452.1};
OS Providencia sneebia DSM 19967.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Providencia.
OX NCBI_TaxID=1141660 {ECO:0000313|EMBL:EKT59452.1, ECO:0000313|Proteomes:UP000010290};
RN [1] {ECO:0000313|EMBL:EKT59452.1, ECO:0000313|Proteomes:UP000010290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19967 {ECO:0000313|EMBL:EKT59452.1,
RC ECO:0000313|Proteomes:UP000010290};
RX PubMed=23145767; DOI=10.1186/1471-2164-13-612;
RA Galac M.R., Lazzaro B.P.;
RT "Comparative genomics of bacteria in the genus Providencia isolated from
RT wild Drosophila melanogaster.";
RL BMC Genomics 13:612-612(2012).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKT59452.1}.
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DR EMBL; AKKN01000006; EKT59452.1; -; Genomic_DNA.
DR RefSeq; WP_008914999.1; NZ_CM001773.1.
DR AlphaFoldDB; K8WPR0; -.
DR PATRIC; fig|1141660.3.peg.1154; -.
DR HOGENOM; CLU_018816_15_0_6; -.
DR OrthoDB; 9811754at2; -.
DR Proteomes; UP000010290; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010290};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..348
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 62..290
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 393 AA; 43448 MW; AAD9C400C21D4AEF CRC64;
MSTQEELQHT TKPPRNKKRQ RKNALILLML FFIAIGVGWS IYWFLVLRHY ESTDNAYVAG
NQVQIQSQIS GSVMTVNVDN TDFVKSGEIL VELDPRDAEL SLDKAKTTLA NSVRQSHQQI
INSRQYQANI DMKKSELVRL QNDLKRREVL GSSNLIGKEE LQHAREAVVS ARAALEVAVE
QLNANNAIVL DTPLAKQPAV EQAATEVRNA WLALQRTKIV SPVDGYVSRR SVQVGSQITT
ATPLMAIVPS QGMWIDANFK ETQLADMRIG QPAKVTLDFY GKDIVFNGTV VGLDMGTGSA
FSLLPSQNAT GNWIKVVQRL PVRIALEPTQ LEKYPLRIGL STEVTVDTLN KDGKVLSKDM
RSAPAYHTSA LAIDMSPADK IVTEIINNNS GNK
//
