ID K8WWP4_9GAMM Unreviewed; 702 AA.
AC K8WWP4;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Alpha-hemolysin translocation ATP-binding protein HlyB {ECO:0000256|ARBA:ARBA00015531};
GN ORFNames=OOA_09418 {ECO:0000313|EMBL:EKT61812.1};
OS Providencia burhodogranariea DSM 19968.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Providencia.
OX NCBI_TaxID=1141662 {ECO:0000313|EMBL:EKT61812.1, ECO:0000313|Proteomes:UP000009336};
RN [1] {ECO:0000313|EMBL:EKT61812.1, ECO:0000313|Proteomes:UP000009336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19968 {ECO:0000313|EMBL:EKT61812.1,
RC ECO:0000313|Proteomes:UP000009336};
RX PubMed=23145767; DOI=10.1186/1471-2164-13-612;
RA Galac M.R., Lazzaro B.P.;
RT "Comparative genomics of bacteria in the genus Providencia isolated from
RT wild Drosophila melanogaster.";
RL BMC Genomics 13:612-612(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Protein-1
CC exporter (TC 3.A.1.109) family. {ECO:0000256|ARBA:ARBA00006025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKT61812.1}.
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DR EMBL; AKKL01000023; EKT61812.1; -; Genomic_DNA.
DR RefSeq; WP_008911899.1; NZ_KB233222.1.
DR AlphaFoldDB; K8WWP4; -.
DR STRING; 1141662.OOA_09418; -.
DR PATRIC; fig|1141662.3.peg.1910; -.
DR eggNOG; COG2274; Bacteria.
DR HOGENOM; CLU_000604_95_4_6; -.
DR OrthoDB; 6828292at2; -.
DR Proteomes; UP000009336; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030256; C:type I protein secretion system complex; IEA:InterPro.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR GO; GO:0030253; P:protein secretion by the type I secretion system; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd18588; ABC_6TM_CyaB_HlyB_like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR010132; ATPase_T1SS_HlyB.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005074; Peptidase_C39.
DR InterPro; IPR039421; Type_1_exporter.
DR NCBIfam; TIGR01846; type_I_sec_HlyB; 1.
DR PANTHER; PTHR24221:SF662; ALPHA-HEMOLYSIN TRANSLOCATION ATP-BINDING PROTEIN HLYB; 1.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF03412; Peptidase_C39; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50990; PEPTIDASE_C39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 152..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..121
FT /note="Peptidase C39"
FT /evidence="ECO:0000259|PROSITE:PS50990"
FT DOMAIN 152..431
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 464..699
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 702 AA; 79066 MW; BB20BE5D0F0E8686 CRC64;
MATNQNNYGL EALVWIANYY QKNVTKDQLM HSIGMQSISP TDWEIRECAH ISGYETSLLA
LDKPILTDIP LPALICLNGY WLVLSKNKDD EHILIHPETG EQSKWCNYKL NETANISLLL
VKEQFESEQK IKFGIGWFIP SILRQRSQLK NIFILAAIVQ LFALISPLLF QNVIDKVLVG
RSLNSLHVLA IAIVSISFAE PIYSFIRNKI FSHTSTQISA ELSGKLYRHL MALPLNYFKL
RPTGKIIARI REMAHIRQFL TGSTLMLFID LLFVSLFIAV LFSYSAIMSW ILIGSLVVFF
ILWMILGPII RQQTEKSYQA DENGLTFLTE AITGIETIKT TATEKYFYQR WQKLLSKQLT
QGFKVSIRSE VASQLMTLVS KITIAALLWV GVKEVMNGGI TPGELVAYNM LSAHVTQPVL
RLAQIWQDFQ HTIISLRRVG DILDEPVENE RKGIVSSASI QGQIDFQNIR FRYQPETPEV
LNNLSLSVKA GEFIGITGPS GSGKSTLTKL LQRLYIPQHG QVIVDGMDLS VSDTVALRRR
MSVVLQESML FVGTIKENIR LSKPQASDHD IIQSAKLAGA YEFVMSLPDN FDYHLSERGL
NLSGGQRQRI ALARALLTEP DILILDEATS ALDYESEAAI MANMPLITKG RTVISIAHRL
NTIMHADKIC VIRDGEVAEM DTHENLLQQN GVYAHLWQQQ TS
//
