ID K8YPX5_NANGC Unreviewed; 525 AA.
AC K8YPX5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=NGA_0599300 {ECO:0000313|EMBL:EKU20735.1};
OS Nannochloropsis gaditana (strain CCMP526) (Green microalga)
OS (Microchloropsis gaditana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Eustigmatophyceae;
OC Eustigmatales; Monodopsidaceae; Nannochloropsis.
OX NCBI_TaxID=1093141 {ECO:0000313|EMBL:EKU20735.1, ECO:0000313|Proteomes:UP000009377};
RN [1] {ECO:0000313|Proteomes:UP000009377}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP526 {ECO:0000313|Proteomes:UP000009377};
RX PubMed=22353717;
RA Radakovits R., Jinkerson R.E., Fuerstenberg S.I., Tae H., Settlage R.E.,
RA Boore J.L., Posewitz M.C.;
RT "Draft genome sequence and genetic transformation of the oleaginous alga
RT Nannochloropis gaditana.";
RL Nat. Commun. 3:686-686(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JH470725; EKU20735.1; -; Genomic_DNA.
DR RefSeq; XP_005855629.1; XM_005855567.1.
DR AlphaFoldDB; K8YPX5; -.
DR EnsemblProtists; EKU20735; EKU20735; NGA_0599300.
DR GeneID; 17362397; -.
DR KEGG; ngd:NGA_0599300; -.
DR OMA; FIMATCF; -.
DR OrthoDB; 36993at2759; -.
DR Proteomes; UP000009377; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF41; MFS_1_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009377};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 338..525
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 56246 MW; 9E0BEE6A8FE1C04F CRC64;
MRSPGSKADG ALPVDRPARR PSLTGGRPSS RPSSHLQDKT AESLAALDDT VSQLCRRVRG
GSVSERSVPA VPKGASPSTA PVALQTGDGP PSMASTLVTV KLLFLLFYGS LGAVMPYLPV
YYHSLGLPDK QIGMLGAITP AVTFVVAPLW GALADQTGRH KDVLLFTFVA SVVSRLLFIW
RTTFGWLAIL VFCTAVLNAP VRPLLDSSVL NLLEDKREYG KQRLWGQFGF GLAGCIVGPC
LMNHKFGGYK AAFYVHALIS LPTLLIMRRF NPTPPAPAPS SPPLPVASTN KSEKSSMAKE
EGPGAVALPS KAPSAALSSQ PAKPRFREGL GIVVRNPDAL IFFFLVFVIG VSSGVIENFA
YKRLREVGGE GTVMGVSRFF SSVTGVPMFW FSGNVTRRLS VMGVLILSLC SYILRFFIYA
SITNPWQGLP AEALRGFTFA AMWASSTYYT HKISPPGLSA TMLGFLNGMY GGLGQSTGAL
IGGGLSHRVG TPRTFVLAGL ADIVVVICFG TYWWLHPNAT RLKEE
//
