ID K9E8J0_9LACT Unreviewed; 580 AA.
AC K9E8J0;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Na+/H+ antiporter NhaC-like C-terminal domain-containing protein {ECO:0000259|Pfam:PF03553};
GN ORFNames=HMPREF9698_01284 {ECO:0000313|EMBL:EKU92978.1};
OS Alloiococcus otitis ATCC 51267.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Alloiococcus.
OX NCBI_TaxID=883081 {ECO:0000313|EMBL:EKU92978.1, ECO:0000313|Proteomes:UP000009875};
RN [1] {ECO:0000313|EMBL:EKU92978.1, ECO:0000313|Proteomes:UP000009875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51267 {ECO:0000313|EMBL:EKU92978.1,
RC ECO:0000313|Proteomes:UP000009875};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Huys G., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Howarth C., Imamovic A., Larimer J., McCowen C., Montmayeur A.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Alloiococcus otitis ATCC 51267.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU92978.1}.
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DR EMBL; AGXA01000029; EKU92978.1; -; Genomic_DNA.
DR RefSeq; WP_003778918.1; NZ_JH992961.1.
DR AlphaFoldDB; K9E8J0; -.
DR STRING; 883081.HMPREF9698_01284; -.
DR PATRIC; fig|883081.3.peg.1461; -.
DR eggNOG; COG1757; Bacteria.
DR HOGENOM; CLU_018751_0_1_9; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000009875; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR PANTHER; PTHR43478; NA+/H+ ANTIPORTER-RELATED; 1.
DR PANTHER; PTHR43478:SF1; NA_H_ANTIPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009875};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..580
FT /note="Na+/H+ antiporter NhaC-like C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039109506"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 202..535
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 580 AA; 61924 MW; 335F1B63C0BC57DD CRC64;
MKNKALGRRI LVSLTLMATT ILANPLVVQA QDAAEANAER LGMATLLPPI LAIILAFTTK
DVILSLFIGV FSGAYIIQLA SGVNVLMALV TSFTAVVQEM LDALADPWNA GIVLQVMAIG
GLIALISKTG GAQAVAESLA QYAKGPVSTQ LITWLLGLLV FFDDYANALI VGPIMRPVSD
NIGNSRERLA FVIDATAAPV TGMALISTWI GYELSLISEA FNMIGQEVNT YGFFLETLPY
RFYNIFMLAF VVITSITLRE FGPMKDAQLR ARDQGQLVEE DSHVETNDQV VEEGRKGSIW
NAVLPIVMLI IFSFVGFYFD GRQALLAEGG SEIVSILENN PLSFVAIRET FGASDASLVL
FQSALAASII ALIMGVWQKY FSLSDGIESW FDGMKSLMST AGVLILAWSL SSVMGSLGTA
EFLVSQLGTV ISPILLPSII FALGSIITFA TGTSFGTMGI LMPLAIPLAY NLDPGNSQLL
LTTSAAVLAG AILGDHSSPI SDTTIMSSMG AGSNLIHHVR TQLPYVLTVG LISIVFGYIP
SAMGVPVWVL IPVAIVVLVV LVYFIGEPIN VKDSNNIYQD
//
