ID   K9EFR6_9BACE            Unreviewed;       481 AA.
AC   K9EFR6;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
GN   ORFNames=HMPREF9447_04716 {ECO:0000313|EMBL:EKU87970.1};
OS   Bacteroides oleiciplenus YIT 12058.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=742727 {ECO:0000313|EMBL:EKU87970.1, ECO:0000313|Proteomes:UP000009872};
RN   [1] {ECO:0000313|EMBL:EKU87970.1, ECO:0000313|Proteomes:UP000009872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YIT 12058 {ECO:0000313|EMBL:EKU87970.1,
RC   ECO:0000313|Proteomes:UP000009872};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Morotomi M., Walker B.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Bacteroides oleiciplenus YIT 12058.";
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC         Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000018,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKU87970.1}.
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DR   EMBL; ADLF01000023; EKU87970.1; -; Genomic_DNA.
DR   RefSeq; WP_009132179.1; NZ_JH992945.1.
DR   AlphaFoldDB; K9EFR6; -.
DR   STRING; 742727.HMPREF9447_04716; -.
DR   PATRIC; fig|742727.4.peg.4814; -.
DR   eggNOG; COG0076; Bacteria.
DR   HOGENOM; CLU_019582_2_2_10; -.
DR   OrthoDB; 9803665at2; -.
DR   Proteomes; UP000009872; Unassembled WGS sequence.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES         274
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   481 AA;  54946 MW;  B759CD335F7BD11F CRC64;
     MEDVNFRKGD AKTEVFGSNR MLQPSPVEKI PDGPTTPEIA YQMVKDETFA QTQPRLNLAT
     FVTTYMDDYA TKLMNEAINI NYIDETEYPR IAVMNGKCIN IVANLWNSPE KDTWKTGALA
     IGSSEACMLG GVAAWLRWRK KRQAQGKPFD KPNFVISTGF QVVWEKFAQL WQIEMREVPL
     TLDKTTLDPE EALKMCDENT ICIVPIQGVT WTGLNDDVEA LDKALDAYNA KTGYDIPIHV
     DAASGGFILP FLYPEKKWDF RLKWVLSISV SGHKFGLVYP GLGWVCWKGK EYLPEEMSFS
     VNYLGANITQ VGLNFSRPAA QILGQYYQFI RLGFQGYKEV QYNSLTIAKY IHDEIAKMEP
     FVNYSEEVVN PLFIWYMKPE YAKNAKWTLF DLQDKLSQHG WMVPAYTLPS KLEDYVVMRV
     VVRQGFSRDM ADMLLGDIKN AITELEKLEY PTPTRMAQDK NLPVEAKVFN HGCRSHKKAA
     K
//