ID K9F984_PEND2 Unreviewed; 855 AA.
AC K9F984;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=PDIG_88190 {ECO:0000313|EMBL:EKV04652.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV04652.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV04652.1}.
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DR EMBL; AKCT01000322; EKV04652.1; -; Genomic_DNA.
DR AlphaFoldDB; K9F984; -.
DR STRING; 1170229.K9F984; -.
DR eggNOG; KOG2189; Eukaryota.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; K9F984; -.
DR OMA; FYLWFFL; -.
DR OrthoDB; 1967517at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 425..450
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 462..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 549..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 579..602
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 645..665
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 758..781
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 787..811
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 855 AA; 97707 MW; E9D82FB2056FBFF3 CRC64;
MAPRDTFFRS ADMSLTQLYI ANEIGREVVS ALGEVGQVQF RDLNPDTNAF QRTFTKEIRR
LDNVERQLRY FHQQMEKAAI PMRSSSDFSD TLAAPLASEI DELADRSESL EQRIISLNDS
YETLKKREVE LSEWRWVLRE AGGFFDRAHT QTEDIRQSFD NDEAPLLRDV EHHAPHQNGD
TQGQQSFSEM NIGFVAGVIP RDRIGAFERI LWRTLRGNLY MNQSEIPEPI IDPMTNEEVH
KNVFVIFAHG KNILAKIRKI SESLNASLYG VDENSELRRD QIHEVNTRLG DVGNVLRNTK
NTLDAELSQI ARSLAAWMII VKKEKAVYDT LNKFSYDRAR KTLIAEAWCP TNSLALIKST
LQDVNDRAGL TVPTIVNQIR TNKTPPTFVR TNKFTEGFQT IVNAYGIPKY SEVNPGLYTV
VTFPFLFAVM FGDCGHGTLM TLAASAMIFW EKKLARTKLD ELTYMAFYGR YIMLMMGLFS
IYTGFIYNDI FSKSFTIFPS QWQWPEDIKA GQMVEATLKE GYRYPIGLDW NWHEADNSLL
FSNSMKMKMS VLLGWCHMTY ALCLQYVNGR HFKSKVDIWG NFVPGLLFFQ SIFGYLVLTI
LYKWSVNWQE KGVNPPGLLN MLIFMFLSPG TVEEQLYPGQ SSVQVLLLLV AVAQVPIMLF
LKPFWLRYEH NRARALGYRG LGENSRVSAL DADGDMDGLL GRDSLASDGE GVAMLSQDID
DSEEHEEFDF GDIMIHQVIH TIEFCLNCIS HTASYLRLWA LSLAHQQLSI VLWTMTIGGA
FDQENPVTRV IMIVVSFYLW FVLTICILCV MEGTSAMLHS LRLHWVEAMS KHFVGEGIPF
LPFSFKTLLE EDPVD
//
