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Database: UniProt
Entry: K9FKQ7_PEND2
LinkDB: K9FKQ7_PEND2
Original site: K9FKQ7_PEND2 
ID   K9FKQ7_PEND2            Unreviewed;       384 AA.
AC   K9FKQ7;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=isocitrate dehydrogenase (NAD(+)) {ECO:0000256|ARBA:ARBA00013012};
DE            EC=1.1.1.41 {ECO:0000256|ARBA:ARBA00013012};
DE   AltName: Full=Isocitric dehydrogenase {ECO:0000256|ARBA:ARBA00030683};
DE   AltName: Full=NAD(+)-specific ICDH {ECO:0000256|ARBA:ARBA00030631};
GN   ORFNames=PDIG_58660 {ECO:0000313|EMBL:EKV10175.1};
OS   Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV10175.1, ECO:0000313|Proteomes:UP000009882};
RN   [1] {ECO:0000313|Proteomes:UP000009882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX   PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA   Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA   Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT   postharvest pathogen of citrus.";
RL   BMC Genomics 13:646-646(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH;
CC         Xref=Rhea:RHEA:23632, ChEBI:CHEBI:15562, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.41;
CC         Evidence={ECO:0000256|ARBA:ARBA00000837};
CC   -!- SUBUNIT: Octamer of two non-identical subunits IDH1 and IDH2.
CC       {ECO:0000256|ARBA:ARBA00011567}.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKV10175.1}.
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DR   EMBL; AKCT01000232; EKV10175.1; -; Genomic_DNA.
DR   AlphaFoldDB; K9FKQ7; -.
DR   STRING; 1170229.K9FKQ7; -.
DR   eggNOG; KOG0784; Eukaryota.
DR   HOGENOM; CLU_031953_0_1_1; -.
DR   InParanoid; K9FKQ7; -.
DR   OMA; TCAHKAN; -.
DR   OrthoDB; 143577at2759; -.
DR   Proteomes; UP000009882; Unassembled WGS sequence.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR004434; Isocitrate_DH_NAD.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   NCBIfam; TIGR00175; mito_nad_idh; 1.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF42; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT   DOMAIN          49..376
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   384 AA;  41816 MW;  2FD08C1CB95D383E CRC64;
     MFSRTAQPAR TLIRSASAAS SLGRSIPART FASVQSDIFK PTKYGGKYTV TLIPGDGIGA
     EVAESVKTIF KADNVPIEWE QVDVSGVDAG NKHSEELFRE SLASLKRNKL GLKGILHTPI
     ERSGHQSFNV ALRQELDIYA SISLIKNIPG YETRHKNVDL CIIRENTEGE YSGLEHQSVN
     GVVESLKIIT RAKSERIAKF AFSFALANNR KKVTCIHKAN IMKLADGLFR STFHKVAEDY
     PTLEVNDMIV DNASMQAVSR PQQFDVMVMP NLYGGILSNV GAALVGGPGL VPGCNMGRDV
     AVFEPGCRHV GLDIKGKDQA NPSAMILSGS MLLRHLGLDD HANRISKAVY DVIGEGRTMT
     RDMGGQATTH EFTRAVLDKM EASL
//
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