ID K9FV60_PEND2 Unreviewed; 1256 AA.
AC K9FV60;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=PDIG_86050 {ECO:0000313|EMBL:EKV04941.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV04941.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV04941.1}.
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DR EMBL; AKCT01000316; EKV04941.1; -; Genomic_DNA.
DR AlphaFoldDB; K9FV60; -.
DR STRING; 1170229.K9FV60; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_0_1_1; -.
DR InParanoid; K9FV60; -.
DR OMA; WWFDVES; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1256
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003930632"
FT TRANSMEM 250..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..721
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1053..1076
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1112..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1196..1219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 578..752
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1256 AA; 137999 MW; BAFF4B88EB0D3687 CRC64;
MRLPRAIAAI VGLGSFAPVL VGAQGETKIH ETGRCAIRGH CGKQSIFGGE LPCPDNDLAH
QPEDTVRQKL IDALSSNLKL AEGIIASCPA CRDNFFNIFC TFTCSPDQSL FVNITKTEEN
SSGKRLVTEL DNIWSKEYQS GFFDSCKNVK NGASGGKAID FIGGGAKDDT HFMKFLGDKK
FLGSPFQINY HTEPSGSDTQ GMEALSIKPK ACNDEDKSFR CSCVDCPDVC PELPVISPHN
ICHVGLLPCL SFAVILVYSI FLLFVIALAS YVTYKERRFR KPERVRLLQD PTPSDDEDEG
EVMHRGGYME RSQGVYKLNS VLSTLFHRIG GTCARFPAIT ISSSVIGVAL LSLGWLNFDV
ETDPVRLWVS PSSAAAQEKD FFDQNFGPFY RAEQAFLVNN RPENDSRPLL DYETLTWWFD
VESRVRRVIS LDRALNFNDV CFKPTGEACV VQSVTGYFGG AVSNLDPDTW MDRLGHCTES
PGDPSCLPDF SQPLKPEMVL GGFEDTGNVL DAQALIVTWV VNNYAQGTEE EAKAIDWENT
FQAVLEVVQE EAAERGLRVS FNSEVSLEQE LNKSTNTDAK IVVISYLIMF FYASIALGSV
TVTWRSLLIN PSNALVQSKF TLGIVGIVIV LMSVSASVGL FSAAGVKVTL IIAEVIPFLV
LAVGVDNIFL IVHEFERVNI SHPDEEIDER VARAVSRIGP SIFLSALTET LAFALGVFVG
MPAVKNFAAY AAGAVFINAI LQITMFISVL ALNQRRVQSL RADCVPCLTV RKANSLGLPG
ENYDGQEEES ALQIFIRRVY APFLLDRRVK VGVVIAFLGL LTAGLALIPE VPLGLDQRIA
LPSDSYLISY FNDLDSYFGA GPPVYFVTRN VNVTERDHQK QLCGRFTTCE EYSLPFVLEQ
ESKRPNVSYL AGSAASWIDD FFYWLNPQQD CCKENGKLCF EDRVPAWNIS LSGMPEGPEF
IHYAKKWIDA STDASCPLGG KAPYSNALVI DEKHTTINAS HFRTSHVPLR SQNEFIEAYI
AARRIADGIS RDHHIDLFPY SKFYIFFDQY VSIVRLTGTL LGSAVAIIFV LTSVILGSIA
TGAVVTTTVI MTVVDIIGTM AIAGVSLNAV SLVNLIICVG IGVEFCAHIA RSFMFPARSI
MEKVPAEFRG KDARAWAALV NVGGSVFSGI TVTKLLGVCV LAFTRSKIFE IYYFRVWLAL
VIFAATHALI FLPVALSYFG GGGYFDPASD GGLEANLASR SYRSSLIHDD YDSDEY
//
