ID K9FW26_PEND2 Unreviewed; 6050 AA.
AC K9FW26;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Nonribosomal peptide synthase Pes1 {ECO:0000313|EMBL:EKV12762.1};
GN ORFNames=PDIG_41980 {ECO:0000313|EMBL:EKV12762.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV12762.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV12762.1}.
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DR EMBL; AKCT01000174; EKV12762.1; -; Genomic_DNA.
DR STRING; 1170229.K9FW26; -.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_6_1; -.
DR InParanoid; K9FW26; -.
DR OMA; YPCSRMQ; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 4.
DR CDD; cd19542; CT_NRPS-like; 3.
DR CDD; cd19534; E_NRPS; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 8.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882}.
FT DOMAIN 783..859
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3137..3213
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4238..4314
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5317..5393
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 6050 AA; 669486 MW; 5482FB00D32BC1A4 CRC64;
MPQSTKCYLP RFASTVDGPK CPVSMKTRPT AAQHAQLLTA WNEDRLDSIL RATWALLLHY
YIRSEDICFG YQHLQGDSRS PKSSEHRSTG VNISTIRISI NDNDSLTEVV EKVRANSANP
QVNGSSEAVS EAYHPFNTIF MLRTYDQPAS ASKPILATTL PDECQVRLHV KVLRGDISIF
LEWRKGDMSG EQMKSVATIF EQLLTKILSA ENIAISKLNL FSENDWQRIH KWNSTSPQLY
DRCIHEAIHD QMLSGPDREA VCAWDGSLTF AELDRQASKL ACHLRMLGVG PEVRVALCFE
KSKWNIVAML GVMKAGGAFV PLDPTHPTSR LQALIQSVQA PVVLCSQHLS NKLAPIAENI
IPVCADQLDP LSDPAENLIL ASGVTSQNAA YVLFTSGSTG EPKGTLLEHR AFLSGAMVHG
PGLHIYRESR CLQFAAHTFD ASLAESLTPL IHGACVCIPS EEARLNDIVT TINEMRVSQA
CFTPSFIGFI EIESLPGLES LVLAGEAMSQ SQLATWSKIK LVNGYGPTEA SVASVLNSNV
TPDTDCKDIG LPIGVRTWLV NPDNHDELVP VGCPGELLLE GPPLARCYVN NPQKTNESFI
FDPAWTMFDA ESGSNRRFYK TGDLVRYNSD TGALNYIGRK DTQVKVHGQR IELGEIENQL
SRDLNVNHCS VLFPKAGFSK GRLAAVISST GLLAEQPDSE LEPLRLVSAS KKAGLVPKIR
ERLSARLPTY MVPPVWLCVE ALPLLPSGKL DRKGISTWVA GMENDPDLQN NAFIGVVGTE
ASQPANDREE ALAAVYSRVL NIPQNLLDLN EGFLALGGDS IAAMTCIGLC KKRGFSLSVQ
ELLRSKSIRD LATRAKTIDH LMTYEEAVDE PFRLSPIQTL HFGVRKEGQG HFNQGILTRL
NKPVDERSLR KAVETLVSRH SMLRARFTDT GFATASSQHI TRDIKGSYRW RMHKLDSMEE
VKIHVADSQS SINCFSGPLL AVDYLLVKGQ PNVLSMTAHH LVVDIVSWRI ILEDLEDIIL
NPQKTEASDS SLPFQTWCRL QNEHCNTLRA EHKIATDTLP AAEFSYWGLQ NTQTTYGNVD
CASFEIDPAH TNAILLECHK ALATEPIDLF LAAMLHSFGH AFPDRSLPTI YNEGHGREVW
DSSIDISHTV GWFTILHPVF VSAYKPDNPI DTLMQVKDLR RRVADNGRAD FSSRVLPGQD
HQEPQHPHPF EMSFNYVGQH RDLQRQDGLF QLVDQMAGEA GQGGGAADFG TDTPRFGLFE
ISAMVVAGKV RFNFSFNKFM QHQSRIHQWV SGCQELLVTL AEQLPTLAPR LTLSSFPLLS
LSYPTLDKLL NEKLPAIGIA SVDIVEDIYP CSRMQQGILL GRKRDSSYYA VHDTFEIKAT
GSSKPNLDRL VNAWEQVVSH HAMFRTIFVE NLTPRHPFCQ VVLKSYDATP VILHSSGESD
VIATFDMEDP KNYSDFSPAH RFTICQTPTG RLFARIEMSH AAMDGNSISI ILRDLQLAYA
SRLEERQKPL FKDYMEYLQD TPKEASIKYW CSYLNQAKPC HFPALTDGHQ TVKVLRSIPV
NFGALNELQT VCDKRGITLA NVFNAAWGLT LRAFCGCDDV SFSYMASLRD VPAEGVQWVI
GPVINLLVCR MKVADDAKLS DVLHKVQNDY LESLPYRHTS LIDIQHALKL SDTNLFNSGV
SYRRLSSSKD ATSSDIECVE VGSIHDPAEF PVFINIEAMD TYARIDLNYW TTNLSDSQAA
NVANTYLRCL ENMVSNIDGE IRQLDNLSEE NRAQIMAWNC KTPKPFEKCA HHVVQEIAKK
RPDALAVTAW DGNLTYSKLD QFSSRLASYL VTFGVGPNAI IPVCFEKSVW NIVSTLAVMK
AGGACIPVDT PESLALVEKW IMENAVQVAL ASPEKARALE DAVPYVIPVS ESLLEYLGDE
ILNPVAQPSD IAYVAMTAGT SGAAKSVVLD HSTVMTRAEA FATTMAIADV SRTLQFAPHT
SDAYVVELFA TFMWGGCICV PADIDPISLA ASMNAFHVNV ASITPTAASY FFPKDVPGLR
SIALGGEVVS QNVLDHWQTD DLQLQVLYGT SESSAASFLV FCSQDENEAA LIGKSTSCVS
WVVDPSNHNR LVPIGSVGEL VLEGPVLARG YLDNQSGESD AFINNPSWLS VQREGAKHRM
FKTGDLVRYK SNGSLVFVGR KNDRHACALA SNLTQTQARI DSFLDHKKKC VVESVQLQRE
NVNIEALVAF VVSSNTSPVT FGDCVLQSTT PQLTDTISSL HINLSTSLPG SKVPSFYIPV
SSLPLTFSGK LNRQALRTET RALSSSALEA FEIKRWNGTK TGKHLSRHAS LSEANVAFWK
EYLADVEPCV FPALSHEASD NCRSTRTLNK QTASIHAFSR LSGLPAEILF QFAWALVLRW
YVGSDDVCFG YSTSPSETKV EAEGVATCRF LVQNDRKVQD TLENAKKDSE KIALNIAALD
AVKDQLGLDN TALFNTSMIY RTASNPSKGI NREPSSSSSY KILVEAEVSH SHAQIHFNYS
SETLSSFLVN HVMDMFDQVL DDLIAHNLND RTIGDINVFT ERSARQICDW NAASPPRLEK
CADELIQQQA LLHPRAEAIC SWDKNFTYGQ LEIVSSRLAR HLSYLGIKPE AFVVLCFEKS
AWAVVAQLAV LKAGGAFVSI DPSHPDSRLK MLIDEIDTNL VLCSSSIHAK ISTLCAKSFA
VCQISISQLS DSPLALPGVR PTPENAAYAI FTSGTTGKPK ATVVEHTGLV TTAIALIDAL
HLNSTTRALQ FSNYTFDVSV MEILMILITG GCICIPSEEE RMNNLGGAIR RMEATSISAP
PAIVNTLEPK NVPSLKVIIT GGEKMPANHI DRWADRCVIN AYGPSEATVV ATVGVKVDRD
GNRINNDPTS IGTSPNCRVW IVDPNNYDRL LPVGAVGELI LEGSNIARGY LGNEEKTKAA
FFEKPAWNRH PGLQGVFKRN DRLYRTGDLV RYSNDGSLAF ISRKDTQIKF NGQRIELEEI
EQQCLSCLPE DSQVAVDVVV PEERTIAKGL AAFFTIHDPD SNGGSSDQFA PTIPGADPLL
LPISVSNMDA IQKLKGCLPD LLPQSMMPRL FFPIRNLPFT SSGKIDRRRL RAMVQTLSKD
TLKSYITFNI SDKRNVSSAT ALETKLVALV EKTLELEVGS VTTDDSFFGL GGDSLSAMNL
VGAAQAEGIA LTVSSIFNSP ILIDMAKSCV VSEAIELKKE TTLAFSLLPS GVNLEDLIDE
ITDNCEVSKD LISDIYPCSA VQEGLLTLSI KHHGAYVAQP TFRLAPGIDI GRFKQAWQQT
VADLEILRTR IVHTEAMNFA QVILKNGPIS WVEAESFDAL PNDILHLPKQ NGAPLTGYAM
VQPPDSSDSY FVWSVHHALY DGWSIPLVFR KVEENYFASQ TKRACMPYSL FINYLAKKNM
EESDSFWKSY LTDLSSTAFP LNKNAVPDAM RAGNTQHHSM RVFRSRDSVD FTIPVLMRAA
WAIVIATHTA SGDVCFGETL SGRNIDLPGV ADIAGPVLTT VPTRVQVDNA MSTMEYLQKI
HQSTTEMIPH LHSGLQRIRQ LNKNTATGCD FKNLLVIQPG DGELDNKIWI DEKRETSEDF
FTHPLVVECG VTKTNISFTV HHDELVINGW QTKRITAQFA HVLQQLIAMP KNSMSKLGDL
EVISPEDKAE IGTWNQRTPL TVERTVHDII REKCDETPNA QAVCAWDGDL TFKEFWDLAS
GFANYLVSRG VGPEVFVPVC LDKSAWAMVT LISVLIAGGG YVPLDPSHPT SRHEEILADV
GATMILCTPN YANRYSRVVK TVVPISKETI KAYGALKSSA RRQTQIKPSN MAYALFTSGS
TGRAKGIIVE HRNVVSSIMA FAPWVRMDET SRVFQFASLT FDAAVMETIA ILMLGGTICV
PSEDDRLNDV AGAIRRLNVT WTFLTPSIAS IIEPSSVPSL KHLVCGGEKM SNEVITKWAN
SVHLMNGYGP TETCVFAVVD NAVATNRDPG RIGYGIPSTL TWIVDPDNHD RLTPLGAVGE
LALEGAPLAR EYLKNPEKNA EAFTTDPAWI KDFAPTVLGP RRIYKTGDLC YYNPDGSVQY
ISRKDHQVKL HGQRMELGEI EHRLSEDALT RHAVVVLPKN GPLKQRLVTV LSLNSVAADT
KLISDKPCEL VDEDELERHA YNELVEVQTN LENQLPIYMV PQTWALIKKL PMLVSGKLDR
KKITAWVEDI DDVSYDRIMA DYDRIKRGKT QEKRQEKQEK NGSLDTVRDI FAQVLNISLQ
KVNVDRSFVS LGGDSITGMA VISRARKQGL VLTLHDILQS RSVKELAQTV SSKVPVARRE
EKSGEGFTLS PVQLLYFQSS DSFKGTARFN QSITVRIVRR CEGEVLKRAL KAVVSQHAMF
RARFSKSSDG TWQQKTAAEV DESFRFRVHS VGDNRAMVPK IADSQTCLDP LNGPILAADL
FNLRTGGQVL FLVAHHLCID MVSWRIVLQD LEELVVSGSL SLEKPLSFQS WCAMQTERAK
THDSTISLPF TIEKPNLLYW GMQESLNVYG DIKMESFSLS EDTTQFILDG CHNVFRTDTV
DILLSAIIHS FGRTFTDRKV PTIYNEGHGR EPWEAEIDLS RTVGWFTTMA PLLVDSEARA
LNEIIKRVKD IRRKTADNGR PYFAKSLLHD QAADFPVPLE ILFNYLGKMQ QLERDDSLFH
HHGSVFDSSD FAVAGDMGPK TARFALFEVS AIVIKDRLNV AFTYNSQMQH GGSIRRWIAQ
CKQTLEKDLL TLKTATPEPT LSDYPLLPIN YHGLQMLTAS TFRKAGIRNK DDVEDIYPCS
PMQEGLLLSQ LRDPNAYMFH TVFEIKDTKS GKVDAEGVAR AWQVLVDRHP VLRTIFVDSN
YTGGSFDQLV LNKISDNILR VECENAQVEE KLAAISLRDR NAMRQSKLSH QLTVCKTNTG
RVVLKLEINH AIIDGGSVDV ILRDLTLAYE RKISEGSGPL FSDYIKFIRT QSQSDALIHW
KRYLDGVHPC HLAQSAVFEA KRELKGVMMN FQRFPELLKF CECSSVTLAN LTLSAWAIVL
RQFTGSDDVC FGYLSAGRDA PVNGIQDMVG IFINMLCCRV QFSDQQTLTD VSKNVQDDYI
RCIPHQSCSL ASIQHELGWQ GQSLFNTTLS IQNHSVAGGA KEKGLSFDLQ HAHDPSEYAV
TVNVEIARGQ EGILLRYWND VVSDEQAQSL AETIAKVFSG FIESPAATLS QSTFSAAAEP
ELLDWDRSQT TLADKAKSTG DAIDSCAIQK IIDDRVHEII GQMLREGKLT VPPISTEGLS
SYGGHTDTVP DSPYQLGVQE ADDSGVCSAT SCSSEDGMSA DMERKLWNLW STALGLSPNV
VRHQESFFKL GGDSITAMKM VSAAREEGLV LTVADVFNNP VFEDMLTTVR AANVTQQILN
VDLKSGAHKE VDSDLLNITP TELGPSPSTE SLEYLRPSCV DDAAVQSGIC PKIGVFKGGI
ADVLPVTDFQ AMSLTATLFK SRWMLNYFYL EGNGSLDLRR LRESCLKVVA AFDILRTVFV
CFHDQFFQVV LRKIRPSIFV YETDRALDEF TMTLQQRDRE YGSREGEQYV QFYVVKKKGS
DQHRILIRLS HTQYDGVCLP KIMSAIKHGY EGTPLPPATP FAGYLRQLPG TITPDHYRHW
TDLLKGSQMT QVVRRKGTSM FQNVGAFTEI HRKIEISPTA LGNVTIATVM QAAWALALAK
LSAQSDVVFG LTISGRNATV PGIESTVGPC VNVIPVRVKL DEKWTGVDLF RYLQDQQVSN
MPFESLGFRE IIKQCTDWPD WTYFTTSVFH QNVDYEGTME LDNNKYRMGG VGVNDNLADL
TMVSRPSGER GLDVTLGYSE KGPVMPFFAS KVLDMACEIA QSLVANPTAS LPSASMLRSL
PLQTIDDLSR PSDEHFLSAH LKSRSIAELL VHSDILSHSW HRVLPSRTAI ASVDPDTDEK
PATQPNFQLD SSFFDLGGDV FHLAQLTWLL EQEGLKVRLE DLIEHPSFLG QMAVLALHNA
KHQDEIPNES LATGAASPDP VARIEKKKTW SKAMTIARKL TGRNTITARA
//
