ID K9FX96_PEND2 Unreviewed; 599 AA.
AC K9FX96;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Probable lysosomal cobalamin transporter {ECO:0000256|ARBA:ARBA00017088};
GN ORFNames=PDIG_82230 {ECO:0000313|EMBL:EKV05681.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV05681.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to export
CC cobalamin from lysosomes allowing its conversion to cofactors.
CC {ECO:0000256|ARBA:ARBA00025515}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00009901}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV05681.1}.
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DR EMBL; AKCT01000299; EKV05681.1; -; Genomic_DNA.
DR AlphaFoldDB; K9FX96; -.
DR STRING; 1170229.K9FX96; -.
DR eggNOG; ENOG502QQ2T; Eukaryota.
DR HOGENOM; CLU_028341_1_0_1; -.
DR InParanoid; K9FX96; -.
DR OMA; FWAQFVF; -.
DR OrthoDB; 8533at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR16130:SF2; LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1; 1.
DR PANTHER; PTHR16130; LYSOSOMAL COBALAMIN TRANSPORTER-RELATED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 599 AA; 67216 MW; 1AFAFC69E979D47F CRC64;
MILLQTSLIW VVYGAVVAIL LAVASVFIYV YQNPRDRSPS VTVTCIISIA SLLATVLLLP
VDVALVSSTT SSKLGQRKDW ATQDLVDRIT YSLTIIYYLL YSLDALLCLL VIPFTYFWYE
ECDEVATEEG AQTLGQRLWG ALKYTLSFVV VVMILFLVGF FVPMSQGKNA MDLDYFRHLL
TENHGERALT FALGLLMTIG LCFYVLYTSV GLALLPISLI KTAPSISSAT LRASTTQKLN
INQERQRQLE GRCAGDPELL SSKDRRELDT LVREERTLIR RQRLAEESQG EGRSRLIRAW
YKIGAAFRPF KLLGGILLLF IAFITWVSML LTVIDKAKNS ICKHRCGYIL VHVNIFNPVN
WALVKSARFF PIDYAIFTAL VMLFFCSSVL GIAVVRIRFL WINIFQIRKG HTSPQALLLA
TAMLMLIILA LNYSISMVVA PQYATFGQQT FCDRAPGTFI GKPDCSNSQE LIKPCSELAK
NPVAQQVCTP SVVSTFLNRV TLNYPFFGVV FFWAQFVFLG KSNSIRIPCL HRSNIDATGL
YLVVFVTSLL RSPQLDEAQL DEDAEEAEEE GLLANTGRRF NASWQDIIGR ATRSERPQG
//
