ID K9FZN1_PEND2 Unreviewed; 1026 AA.
AC K9FZN1;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 03-MAY-2023, entry version 38.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|RuleBase:RU366037};
GN ORFNames=PDIG_35300 {ECO:0000313|EMBL:EKV14047.1};
OS Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV14047.1, ECO:0000313|Proteomes:UP000009882};
RN [1] {ECO:0000313|Proteomes:UP000009882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT postharvest pathogen of citrus.";
RL BMC Genomics 13:646-646(2012).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466, ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKV14047.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCT01000147; EKV14047.1; -; Genomic_DNA.
DR AlphaFoldDB; K9FZN1; -.
DR STRING; 1170229.K9FZN1; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; K9FZN1; -.
DR OMA; HEMFLFG; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000009882; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 104..266
FT /note="Exportin-1/Importin-beta-like"
FT /evidence="ECO:0000259|Pfam:PF08389"
FT DOMAIN 341..1024
FT /note="Exportin-T C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19282"
SQ SEQUENCE 1026 AA; 114030 MW; 1B5F962C40F1133A CRC64;
MEEQVANAIE IAWNPSSDPT LKSQAYEYLN QLRSDPSGWQ VCLSLFTKTP QQPEVVRHVS
LEIVNSAAQV GLINPASLGV VRDSVLAYVR QAYGPEATAT PDAPYIQNKI AQTVTFLFSS
LYANGWETCI DDLLNLTCKS AGWDSQIGVV FYLRVLSSIH EEIGDVLVSR SRGEQDRANA
LKDLIRERDM QKIANSWQEI LAVWRESDDT IVEMCLKAVG SWVSWIDIGL VVNQTMLDLL
FQQLGRAEKQ ELREGEQRVR DAAVDVFTEI IGKKMKPSDK IEMIAFLNLD SIITQLSNSP
PLRESRFTFK YDTDLAETVA KLVNNTVVDI VRVLDNDAGP VKEQAENLLQ VFLPHILRFF
SDEYDEVCST VIPCVSDMLT YIRKLAKANP SFAERNKSIL LPILKAIIAK MRYDETSNWG
EEDEQTDEAE FQDLRKRLGV LQQIIASADE QLYIDAISEV VGTTFQKLRA SGGQLDWRDL
DLALHEMFLF GDLAVRGGSL YLKGAPTGMA ANRLIEMMLA MVESDIRSFT HPATQLQYME
ICVRYSSFFT HNTHLIPGVL ESFLQLVHHP VKKVKTRSWY LFQRLARQLR SQIGNVAQTV
VEALSDLLVI QAEVPSEGDD GDEMSSEDHE GSADAVFNSQ LYLFESVGII SSTPSVVAEK
QVLYAQSVMN PVFGDMERNL EAAKANDERA LLQIHHDIMA LGTLARGYSD WQPGTSSPSA
LPAPEVSAAF AQVAEATLVA LESLSSSFNI RTAARFAFSR LIGVLGAQIL PQLPRWIDGL
LTQTSSRDEM ALFLRLLDQV IFGFKGEIYS ILDTLLTPFL QRVFSGIADP TTGTDDEIQL
AELKREYLNF LLAVLNNDLG TVIISERNQP IFETVITTIE HFAKDIDDFT TAKMAFSVLG
RMASCWGGPD IAPAPANGAA PAQAVLPGFG GFMITRFSPL CWALPTTPSF NSKDAQAKQV
LAEAGALQRT IYSKTGMEYA EYLRNQELPG MGMGADLIEE FLTALSQLDV KGFRQFFPSF
IQRLSA
//
