ID   K9GAW0_PEND2            Unreviewed;       925 AA.
AC   K9GAW0;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Transmembrane GTPase Fzo1, putative {ECO:0000313|EMBL:EKV18272.1};
GN   ORFNames=PDIG_10450 {ECO:0000313|EMBL:EKV18272.1};
OS   Penicillium digitatum (strain PHI26 / CECT 20796) (Green mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1170229 {ECO:0000313|EMBL:EKV18272.1, ECO:0000313|Proteomes:UP000009882};
RN   [1] {ECO:0000313|Proteomes:UP000009882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHI26 / CECT 20796 {ECO:0000313|Proteomes:UP000009882};
RX   PubMed=23171342; DOI=10.1186/1471-2164-13-646;
RA   Marcet-Houben M., Ballester A.-R., de la Fuente B., Harries E.,
RA   Marcos J.F., Gonzalez-Candelas L., Gabaldon T.;
RT   "Genome sequence of the necrotrophic fungus Penicillium digitatum, the main
RT   postharvest pathogen of citrus.";
RL   BMC Genomics 13:646-646(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001270};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004374}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKV18272.1}.
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DR   EMBL; AKCT01000039; EKV18272.1; -; Genomic_DNA.
DR   AlphaFoldDB; K9GAW0; -.
DR   STRING; 1170229.K9GAW0; -.
DR   eggNOG; KOG0448; Eukaryota.
DR   HOGENOM; CLU_011752_0_0_1; -.
DR   InParanoid; K9GAW0; -.
DR   OMA; RCERMIL; -.
DR   OrthoDB; 1381184at2759; -.
DR   Proteomes; UP000009882; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProt.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   PANTHER; PTHR10465:SF0; TRANSMEMBRANE GTPASE MARF-RELATED; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000313|EMBL:EKV18272.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009882};
KW   Transmembrane {ECO:0000313|EMBL:EKV18272.1}.
FT   DOMAIN          278..563
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          501..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        514..537
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   925 AA;  102011 MW;  46F3C10CFA1941CC CRC64;
     MSQEYHPVEG SSSGAGSSRF SGEEEFPEKN PFFRPPPTYM TVGNGSTSDS ATALMTSLNQ
     DSGYGGSVAN TEDDANSAWR AGLMEDRPTP VHTPTRPGEW NPAAEHEKQV VASHVSQLLY
     NSNRTKLARA ISRTIDTLKE LQDMNRQWPA HYPSVQSTSF SPMDRRPSLN QTQSEFGDNN
     SRPSTPPRPE LRRAATLMGS DEMGESSASA QHRITSEPRL MTPQIAQEFS ILKLDLKLGA
     LSQAELVHSL EKASIAALLD GKISQSMKHL LSLRDRIEDT SSKVLITGDL NAGKSTFCNA
     LLRRKVLPED QQPCTSIFCE VLDARENCSV EEVHAVHKDT PYNRNDESTF DVYSLAELEN
     IVVENTKYMQ CKVYVKDVRS IDESLLNNGV VDIALIDAPG LNSDSLKTTA VFARQEEIDV
     VVFVVSAANH FTLSAKEFIL NAAHEKAYIF VVVNGFDQIR DKQRCERMIL DQIGKLSPRT
     YKEAAELVHF VSSNAIPVAP AISQSGSGGG DGGGSDPHDD DDDRDPKNKG KGKEQEKLQD
     FENLEGALRR FVLEKRSRSK LAPARTYLLN LLADLSSLAT VNRDVAQSEL TRVTDELAEI
     IPAFENGKKK KGELAEGINK AIDDSCDDVY GHTRSTLTNT IARVSDADLG VEYPGIFSAF
     QYAEELKLAM LDQIASSVAD CEDYAREKTV QGVGFIQNIG LLHIGEDKFT PLNFRADAMF
     RRGRRHTFGR QVDTEVELWD FFDIAGLWER QEKMAGTGVA MTVVTVLGSR ALGGFSWLDS
     ALSAVKVIGP NNIRRLFIPG LLAAAVLTTA YVLSSIPTTL PPRLSRKIAA TLAEMDYVHS
     NANRISTEVR RMLRMPANNL QTCLSQDIED LGRRKQEVTK IKQESDVATK YFSNLFRDSS
     ENRRSIENLD LDAPLPGGMA AAMQA
//