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Database: UniProt
Entry: K9IVV5_PIG
LinkDB: K9IVV5_PIG
Original site: K9IVV5_PIG 
ID   K9IVV5_PIG              Unreviewed;       476 AA.
AC   K9IVV5;
DT   06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2013, sequence version 1.
DT   24-JAN-2024, entry version 67.
DE   RecName: Full=Tryptophan--tRNA ligase, cytoplasmic {ECO:0000256|ARBA:ARBA00013782};
DE            EC=6.1.1.2 {ECO:0000256|ARBA:ARBA00013161};
DE   AltName: Full=Tryptophanyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030268};
GN   Name=WARS1 {ECO:0000313|Ensembl:ENSSSCP00000049002.1,
GN   ECO:0000313|VGNC:VGNC:94891};
GN   Synonyms=WARS {ECO:0000313|EMBL:JAA53775.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:JAA53775.1};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000049002.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000049002.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:JAA53775.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Dawson H.D., Chen C.T.;
RT   "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT   Sequencing.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HDB77028.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30723633; DOI=.7717/peerj.6374;
RA   Gilbert D.G.;
RT   "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL   PeerJ 7:E6374-E6374(2019).
RN   [4] {ECO:0000313|Ensembl:ENSSSCP00000049002.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-
CC         tryptophanyl-tRNA(Trp); Xref=Rhea:RHEA:24080, Rhea:RHEA-COMP:9671,
CC         Rhea:RHEA-COMP:9705, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57912, ChEBI:CHEBI:78442,
CC         ChEBI:CHEBI:78535, ChEBI:CHEBI:456215; EC=6.1.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000107};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363036}.
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DR   EMBL; DQIR01221551; HDB77028.1; -; Transcribed_RNA.
DR   EMBL; DQIR01223451; HDB78928.1; -; Transcribed_RNA.
DR   EMBL; DQIR01245482; HDC00960.1; -; Transcribed_RNA.
DR   EMBL; DQIR01252701; HDC08179.1; -; Transcribed_RNA.
DR   EMBL; DQIR01267158; HDC22636.1; -; Transcribed_RNA.
DR   EMBL; GACC01000032; JAA53775.1; -; mRNA.
DR   RefSeq; XP_003128776.3; XM_003128728.5.
DR   RefSeq; XP_005656526.1; XM_005656469.2.
DR   RefSeq; XP_013844693.1; XM_013989239.1.
DR   Ensembl; ENSSSCT00000065002.3; ENSSSCP00000049002.1; ENSSSCG00000002516.5.
DR   GeneID; 100515390; -.
DR   KEGG; ssc:100515390; -.
DR   CTD; 7453; -.
DR   VGNC; VGNC:94891; WARS1.
DR   GeneTree; ENSGT00940000153724; -.
DR   HOGENOM; CLU_032621_0_1_1; -.
DR   OMA; SIYHRFM; -.
DR   OrthoDB; 540846at2759; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Bgee; ENSSSCG00000002516; Expressed in caecum and 42 other cell types or tissues.
DR   Genevisible; K9IVV5; SS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004830; F:tryptophan-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00806; TrpRS_core; 1.
DR   CDD; cd00936; WEPRS_RNA; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 1.10.287.10; S15/NS1, RNA-binding; 1.
DR   Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002305; aa-tRNA-synth_Ic.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR002306; Trp-tRNA-ligase.
DR   InterPro; IPR009068; uS15_NS1_RNA-bd_sf.
DR   InterPro; IPR000738; WHEP-TRS_dom.
DR   NCBIfam; TIGR00233; trpS; 1.
DR   PANTHER; PTHR10055:SF1; TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR10055; TRYPTOPHANYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00579; tRNA-synt_1b; 1.
DR   Pfam; PF00458; WHEP-TRS; 1.
DR   PRINTS; PR01039; TRNASYNTHTRP.
DR   SMART; SM00991; WHEP-TRS; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF47060; S15/NS1 RNA-binding domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR   PROSITE; PS51185; WHEP_TRS_2; 1.
PE   1: Evidence at protein level;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363036};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363036};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363036};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363036};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363036};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:K9IVV5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT   DOMAIN          13..69
FT                   /note="WHEP-TRS"
FT                   /evidence="ECO:0000259|PROSITE:PS51185"
SQ   SEQUENCE   476 AA;  53690 MW;  36BE4E7592FEE36E CRC64;
     MADVPNGEQG CSSPLELFNS IAAQGELVRS LKARHAAKDE IDSAVKMLLS LKMSYKAAMG
     EDYKADCPPG NRAPGIDSGL DATEAGDDFV DPWTVQTSSA KGIDYDKLIV RFGSSKIDKE
     LIDRIERATG QRPHRFLRRG IFFSHRDMNQ VLDAYENKKP FYLYTGRGPS SEAMHVGHLI
     PFIFTKWLQD VFNVPLVIQM TDDEKYLWKE LTLEQAHGYA VENAKDIIAC GFDVNKTFIF
     SDLDYMGMSP GFYKNVVKIQ KHVTFNQVKG IFGFTDSDCI GKISFPAIQA APSFSSSFPQ
     IFRDRTDIQC LIPCAIDQDP YFRMTRDVAP RIGYPKPALL HSTFFPALQG AQTKMSASDP
     NSSIFLTDTA KQIKTKVNKH AFSGGRDTIE EHRQFGGNCD VDVSFMYLTF FLEDDDRLEQ
     IRKDYSSGAM LTGELKKVLI EVLQPLIAEH QARRKEVTDE VVKEFMTPRK LSYDFE
//
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