ID K9J6H5_PIG Unreviewed; 465 AA.
AC K9J6H5;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=E3 ubiquitin-protein ligase TRIM38 isoform X1 {ECO:0000313|EMBL:HCZ78941.1};
DE SubName: Full=Tripartite motif containing 38 {ECO:0000313|EMBL:JAA53559.1, ECO:0000313|Ensembl:ENSSSCP00000059249.1};
GN Name=TRIM38 {ECO:0000313|EMBL:JAA53559.1,
GN ECO:0000313|Ensembl:ENSSSCP00000059249.1,
GN ECO:0000313|VGNC:VGNC:94411};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:JAA53559.1};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000059249.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000059249.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAA53559.1}
RP NUCLEOTIDE SEQUENCE.
RA Dawson H.D., Chen C.T.;
RT "Global Gene Expression Profiling of Alveolar Macrophages by Deep
RT Sequencing.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:HCZ78941.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000059249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQIR01023466; HCZ78941.1; -; Transcribed_RNA.
DR EMBL; DQIR01167015; HDB22492.1; -; Transcribed_RNA.
DR EMBL; GACC01000248; JAA53559.1; -; mRNA.
DR STRING; 9823.ENSSSCP00000059249; -.
DR Ensembl; ENSSSCT00000060157.2; ENSSSCP00000059249.1; ENSSSCG00000035153.3.
DR VGNC; VGNC:94411; TRIM38.
DR GeneTree; ENSGT00940000160468; -.
DR OMA; FRVYQHS; -.
DR OrthoDB; 3453019at2759; -.
DR Proteomes; UP000008227; Chromosome 7.
DR Bgee; ENSSSCG00000035153; Expressed in blood and 43 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0046598; P:positive regulation of viral entry into host cell; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR GO; GO:0032880; P:regulation of protein localization; IBA:GO_Central.
DR GO; GO:0046596; P:regulation of viral entry into host cell; IBA:GO_Central.
DR CDD; cd19761; Bbox2_TRIM5-like; 1.
DR CDD; cd16600; RING-HC_TRIM38_C-IV; 1.
DR CDD; cd15815; SPRY_PRY_TRIM38; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR035790; SPRY/PRY_TRIM38.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF47; E3 UBIQUITIN-PROTEIN LIGASE TRIM38; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 16..63
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 88..129
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 274..465
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 133..160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..236
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 465 AA; 53567 MW; 32A14B507F8F3E16 CRC64;
MASTTTTRKM REEATCSICL HLMSKPVSIS CGHSYCHSCI VNFFENLCRM QPWLETFSCP
QCRVPFKMSS LRPNVQLGGL IEAIKEMDQE MSCEEHGEKL HLFCENEGKL ICWRCDRGPQ
HRGHATTLVE DACQGYKEEL QKAVTQLKQL EEECMKLKMF TAKQITEWNE KIEIQKQKIQ
SDFKNLQRFL HEEEKSYLWK LEKEKEQTLR RLRDNKVHLE QQSHELQSHI LELENKCQGS
AQNLLQDVKD TLSRSWAVKL DKPEPLSLDL HTVCNVSERY FDVKKILRSH QVSVTLDPDT
AHYELVLSED RRQVTRGSPQ ENLESSSRRF SALPCILGCE GFTSGKHYFE VDVGEGTGWD
LGVCMENVQR DTGLVQTPQS GFWAIRLCKK KGYVALTSPL TSLQLREQPL VVGIFLDCEA
GVVSFYNMTT GSHIFTFPKA SFSDTLRPYF QVYQYSPLFL PPPDE
//
