ID K9J7G4_MOUSE Unreviewed; 306 AA.
AC K9J7G4;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Vomeronasal type-1 receptor {ECO:0000256|RuleBase:RU364061};
GN Name=Vmn1r242 {ECO:0000313|Ensembl:ENSMUSP00000131047.2,
GN ECO:0000313|MGI:MGI:3782683};
GN Synonyms=Gm4498 {ECO:0000313|MGI:MGI:3782683}, Gm8453
GN {ECO:0000313|MGI:MGI:3644807}, Vmn1r252
GN {ECO:0000313|Ensembl:ENSMUSP00000129429.2,
GN ECO:0000313|MGI:MGI:3644807};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000131047.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000131047.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131047.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000131047.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000131047.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU364061}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU364061}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU364061}.
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DR RefSeq; NP_001160622.1; NM_001167150.1.
DR RefSeq; NP_001160623.1; NM_001167151.1.
DR PaxDb; 10090-ENSMUSP00000129429; -.
DR Ensembl; ENSMUST00000167253.2; ENSMUSP00000129429.2; ENSMUSG00000094149.2.
DR Ensembl; ENSMUST00000168580.2; ENSMUSP00000131047.2; ENSMUSG00000094757.2.
DR GeneID; 100043523; -.
DR GeneID; 667094; -.
DR KEGG; mmu:100043523; -.
DR KEGG; mmu:667094; -.
DR UCSC; uc012fbt.1; mouse.
DR AGR; MGI:3644807; -.
DR AGR; MGI:3782683; -.
DR CTD; 100043523; -.
DR CTD; 667094; -.
DR MGI; MGI:3782683; Vmn1r242.
DR MGI; MGI:3644807; Vmn1r252.
DR VEuPathDB; HostDB:ENSMUSG00000094149; -.
DR VEuPathDB; HostDB:ENSMUSG00000094757; -.
DR eggNOG; ENOG502R0MZ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_1_0_1; -.
DR OrthoDB; 4791882at2759; -.
DR BioGRID-ORCS; 100043523; 2 hits in 24 CRISPR screens.
DR BioGRID-ORCS; 667094; 1 hit in 7 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 7.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062:SF51; TASTE RECEPTOR TYPE 2-RELATED; 1.
DR PANTHER; PTHR24062; VOMERONASAL TYPE-1 RECEPTOR; 1.
DR Pfam; PF03402; V1R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU364061};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU364061};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364061};
KW Pheromone response {ECO:0000256|ARBA:ARBA00022507,
KW ECO:0000256|RuleBase:RU364061};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU364061};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transducer {ECO:0000256|RuleBase:RU364061};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364061};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364061}.
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364061"
FT TRANSMEM 54..71
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364061"
FT TRANSMEM 197..213
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364061"
FT TRANSMEM 240..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364061"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364061"
FT DOMAIN 27..291
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 306 AA; 34342 MW; 0620BE0517FA5F62 CRC64;
MSVHDKSVKT TEEVALQLLL LCQFGVGTVA NVFLFVHNFS PVLTGSKQRP RQVILSHMAV
ANALTLFLTI FPNNMMAFAP KTPPNELKCK LESFSRLVAR STNLCSTCVL SIHQFVTLFP
VSRGKGKLIL RASVQNLASY SCYSCWFFSV LSNIHIPIRV TGPQITDNNT DSKSNLFCST
SGFIVGIVLQ FAHDATFMSI MIWTSVSMIL LLHRHCQRMQ DILTPNQNPR GQAETRATRT
ILMLVVTFVS FYLLNCICII FHAFFIHSRL FIRLVSEVLA AVFPSICPLL LIFRDPKDPC
SLLFKC
//
