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Database: UniProt
Entry: K9PHI3_9CYAN
LinkDB: K9PHI3_9CYAN
Original site: K9PHI3_9CYAN 
ID   K9PHI3_9CYAN            Unreviewed;       363 AA.
AC   K9PHI3;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   18-JUL-2018, entry version 28.
DE   RecName: Full=Alanine dehydrogenase {ECO:0000256|PIRNR:PIRNR000183};
DE            EC=1.4.1.1 {ECO:0000256|PIRNR:PIRNR000183};
GN   ORFNames=Cal7507_2189 {ECO:0000313|EMBL:AFY32628.1};
OS   Calothrix sp. PCC 7507.
OC   Bacteria; Cyanobacteria; Nostocales; Rivulariaceae; Calothrix.
OX   NCBI_TaxID=99598 {ECO:0000313|EMBL:AFY32628.1, ECO:0000313|Proteomes:UP000010390};
RN   [1] {ECO:0000313|EMBL:AFY32628.1, ECO:0000313|Proteomes:UP000010390}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7507 {ECO:0000313|EMBL:AFY32628.1,
RC   ECO:0000313|Proteomes:UP000010390};
RG   US DOE Joint Genome Institute;
RA   Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA   Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Teshima H., Chen A.,
RA   Krypides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA   Ovchinnikova G., Pagani I., Pati A., Goodwin L., Peters L.,
RA   Pitluck S., Woyke T., Kerfeld C.;
RT   "Finished genome of Calothrix sp. PCC 7507.";
RL   Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-alanine + H(2)O + NAD(+) = pyruvate + NH(3)
CC       + NADH. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- PATHWAY: Amino-acid degradation; L-alanine degradation via
CC       dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step
CC       1/1. {ECO:0000256|PIRNR:PIRNR000183}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000183}.
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DR   EMBL; CP003943; AFY32628.1; -; Genomic_DNA.
DR   RefSeq; WP_015128442.1; NC_019682.1.
DR   EnsemblBacteria; AFY32628; AFY32628; Cal7507_2189.
DR   KEGG; calo:Cal7507_2189; -.
DR   PATRIC; fig|99598.3.peg.2452; -.
DR   KO; K00259; -.
DR   OrthoDB; POG091H02R2; -.
DR   BioCyc; CSP99598:G1HCH-2157-MONOMER; -.
DR   UniPathway; UPA00527; UER00585.
DR   Proteomes; UP000010390; Chromosome.
DR   GO; GO:0000286; F:alanine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd05305; L-AlaDH; 1.
DR   InterPro; IPR008141; Ala_DH.
DR   InterPro; IPR008143; Ala_DH/PNT_CS2.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42795; PTHR42795; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   PIRSF; PIRSF000183; Alanine_dh; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00518; alaDH; 1.
DR   PROSITE; PS00837; ALADH_PNT_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000010390};
KW   NAD {ECO:0000256|PIRNR:PIRNR000183, ECO:0000256|PIRSR:PIRSR000183-3};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000183-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000183,
KW   ECO:0000313|EMBL:AFY32628.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010390}.
FT   DOMAIN        4    137       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      149    297       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
FT   NP_BIND     239    240       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     267    270       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   NP_BIND     298    301       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   ACT_SITE     95     95       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   ACT_SITE    270    270       Proton donor/acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000183-1}.
FT   BINDING      15     15       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING      74     74       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000183-2}.
FT   BINDING     134    134       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     198    198       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     203    203       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
FT   BINDING     220    220       NAD. {ECO:0000256|PIRSR:PIRSR000183-3}.
SQ   SEQUENCE   363 AA;  38847 MW;  5B0B048D4E5D15A9 CRC64;
     MEIGVPKETK DQEFRVGLSP SSVRVLRENG HTIFVETQAG TGAGFMDGEY VSAGAEIVPT
     PEAVWHRELV VKVKEPLTTE YKFLHKEQIL FTYLHLAADR KLTEYLIDCG TSAIAYETVE
     QPGANKLPLL SPMSIIAGRL SVQFGARYLE RQQGGRGVLL GGVPGVKAGK VVILGGGVVG
     TEAAKIAVGM GATVQILDVN VERLSYLETL FGSRVELLYS NSAHIEAAVK DADLLIGAVL
     VPGRRAPILV SRELVKQMRP GSVIVDVAVD QGGCVETLHS TSHTNPIYLD EGVVHYGVPN
     MPGAVPWTAT QALNNSTLPY VVQLANLGIK ALAVNPALAK GLNVQNHRLV HPAVQEVFPD
     LVS
//
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