ID K9PKJ7_9CYAN Unreviewed; 1948 AA.
AC K9PKJ7;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=Cal7507_3277 {ECO:0000313|EMBL:AFY33683.1};
OS Calothrix sp. PCC 7507.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC Calothrix.
OX NCBI_TaxID=99598 {ECO:0000313|EMBL:AFY33683.1, ECO:0000313|Proteomes:UP000010390};
RN [1] {ECO:0000313|EMBL:AFY33683.1, ECO:0000313|Proteomes:UP000010390}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7507 {ECO:0000313|EMBL:AFY33683.1,
RC ECO:0000313|Proteomes:UP000010390};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Teshima H., Chen A.,
RA Krypides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA Ovchinnikova G., Pagani I., Pati A., Goodwin L., Peters L., Pitluck S.,
RA Woyke T., Kerfeld C.;
RT "Finished genome of Calothrix sp. PCC 7507.";
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP003943; AFY33683.1; -; Genomic_DNA.
DR RefSeq; WP_015129492.1; NC_019682.1.
DR STRING; 99598.Cal7507_3277; -.
DR KEGG; calo:Cal7507_3277; -.
DR PATRIC; fig|99598.3.peg.3714; -.
DR eggNOG; COG0515; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR eggNOG; COG4191; Bacteria.
DR HOGENOM; CLU_000445_34_2_3; -.
DR OrthoDB; 573511at2; -.
DR Proteomes; UP000010390; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0009882; F:blue light photoreceptor activity; IEA:UniProt.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00130; PAS; 1.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:AFY33683.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010390};
KW Transferase {ECO:0000313|EMBL:AFY33683.1}.
FT DOMAIN 19..278
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1615..1666
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1693..1948
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 1516..1546
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1657..1684
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1948 AA; 218965 MW; 0E9A7F355DB496BC CRC64;
MEISNSSVSL TTKLELPGYY ITEELYSGSR TQVYRGVQEA NQLPVVIKLL KRQYPTFNEL
VQFRNQYAIA KNLDIPSIVK PYSLEPYHNG YALVMEDFGG ISLREFTKGQ PLTLEQFLRI
ALQLTDTLHQ LHQKQVIHKD IKPANILIHP DTKQVKLIDF SISTLLSKEI PQIQSFNTLE
GTLAYLSPEQ TGRMNRGVDY RSDFYSLGVS FFELLTGQLP FQTHEPMELV HCHIAKQPPT
VISEEIPQVI SDIVMKLMAK NAEDRYQSGL GLKYDLQLCW EQLQETGKIE DFAIAQRDMS
DRFIIPEKLY GREQEVEALL EAFERVGDGA SELMLVAGFS GIGKTAVVNE VHKPIVRCRG
YFIKGKYDQF QRNIPLSAFV QAFRDLMRQL LSENDTQLSA WITKILAALG ESGQVLIEVI
PELEQIIGRQ PPVPQLSGSA AQNRFNLLFQ KFIQVFSTPE HPLVIFIDDL QWADSASLKL
MHLLMSESNN GYLLLVGAYR NNEVTPAHPL MFTLDEIRKT PVNINTINLH KLSYLKLNQL
VADTLGCSEE LAFSLSRLIY QKTEGNPFFA TQFLKSLYQN GLIKINLEKQ YWQCDITQIN
QEALTDNIVK FMAFQLHRLP QSTQNILKLA ACIGNQFDLK TLAIISEMSE TETAADLWNA
LQEGLILPQS EVYKFYQESE IRLQKSGESI IAADSCAYKF LHDRVQQAAY SLIPDDQKQA
THLKIGQLLL QKDQGEKLFD IVNHLNVGQS LITEPSQRHK LAQLNLAAGR KARAATAYSA
ALTYLKTGID LLPSDRWQHQ YNLSLALYEG AIEAAYLSTN FAQMEELAAT VLTHAHSWLD
RVTTYEAKIQ ASIAQNQHLE ALRQAREVLE QLGVYLPEQP TQVEIKQGLQ HTQTLLGKRS
IESLLELPEM TALEPKAAMT IISSILSVAY QVAPNLLPLL IFVQVDLSVQ YGNATESTYG
YAMYGLMQVA MLKDIDAGYR FGQLGMNLLQ RMDNPKFAAK TIFGFNTSLR HWREPVKDTL
IGYLQAYASG LETGDLEYVA LSLMCHSYTA YFSGQELAAL KQMMDEHRKV IQQFRQHGYF
RIQSIYYQAV LNLLEPTTEP DRLCSKDYDE DEMIQLHLQA NQLLALCQLY FNKLLLSYLF
HRYKQALENA HLTAQYLEAA VGLMHVPLFS FYDALLRLAI YPTASQTEQV ALLDQVCAHH
EKLQEWASYA PSNQAHRCAL VAAERCRVLG EKAEAIDFYD RAISGAKEQG YIQEEALANE
LAARFYLNWS KERIAGEYIT QAYYGYARWG AKAKVADLEK RYPQLLAPIL QQIRSPFSTH
ETLFTLESVT STSSPTSSSS SVSVALDLAA ILKASQSLSG EIELEKLLSV FLHVVIENAG
ADKCVFMLLE SGSLLIQALA ELSLSKVEFY PMLLNPQPVE DSVDVPVGLI NIVKRSLKPA
VIIDATVHPQ LINDPYIQQQ QPKSILCSPI LHQGKLLGVL YLENNLATGV FTRDRVELLN
LLCSQAAISL ENARLYQNSQ NYAQQLEQSL AKLQASEIRF QNLANNIPGM VYQFRLGVDG
SASTPYVSAG CWNLYELEPE SVMAGKHSLY ALHHPDDHPA IAQAIAYSVE NLTPFKQEWR
IILPSGTVKW VQSAARPQRQ ADGATLWDGV VIDISDRKQV ELALQQKSQD LQQAQLQMIQ
SEKMSALGNL VAGVAHEMNN PLGFITASLK QAKPTLADIT EHLKLYQASL PNKSEEILEH
AAEIDLEYSL QDLPQMIDAM VMASDRLKNI STSLRTFSRA DKDYKVPFNI HEGIDSTILI
LKHRLKANEQ RPAIEIITNY NNLPQIKCFP GQLNQVFMNI LANAVDALEE SNHGRSYYEI
KENPNRIKIT TSVANSQIKI AIADNGIGMS ESVKQKIFDH LFTTKSVGKG TGLGLAIARQ
IVTEKHGGVI EVDSTPGEGT EFVIQLPL
//
