ID K9QNN3_NOSS7 Unreviewed; 2317 AA.
AC K9QNN3;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Polyketide synthase family protein {ECO:0000313|EMBL:AFY47240.1};
GN OrderedLocusNames=Nos7524_1360 {ECO:0000313|EMBL:AFY47240.1};
OS Nostoc sp. (strain ATCC 29411 / PCC 7524).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=28072 {ECO:0000313|EMBL:AFY47240.1, ECO:0000313|Proteomes:UP000010378};
RN [1] {ECO:0000313|Proteomes:UP000010378}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29411 / PCC 7524 {ECO:0000313|Proteomes:UP000010378};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC subfamily. {ECO:0000256|ARBA:ARBA00006714}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP003552; AFY47240.1; -; Genomic_DNA.
DR RefSeq; WP_015137694.1; NC_019684.1.
DR STRING; 28072.Nos7524_1360; -.
DR KEGG; nop:Nos7524_1360; -.
DR PATRIC; fig|28072.8.peg.1483; -.
DR eggNOG; COG0764; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_30_0_3; -.
DR OrthoDB; 499075at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000010378; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:InterPro.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01287; FabA; 2.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR010083; FabA.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07977; FabA; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Reference proteome {ECO:0000313|Proteomes:UP000010378};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 1..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 469..925
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT COILED 949..979
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2317 AA; 258164 MW; F793635928B3B9D1 CRC64;
MTPIAIIGLS CLFPGAENPE KYWQNLIEQK DLTSLANQEQ MGVDANFFYN SIKGKTDKYY
CMKGGYIRDF QFDAAGYEIA PEILQKLDQL YQWSLYVSRQ ALKDSGYLKN RSVLSNCGVI
LGNLSFPTRF SHRIFASTYH KVINSAIQEL LQDKLLHLPK LSNDLSPLNA LLSGYPAALI
AQALSLSGIN FSLDAACASS LYAIKLACDY LLSGKADLML AGAVSCADPL FIHMGFSIFQ
AYPENSVTRP LDKSSGGLIS AEGAGMVVLK RYDDAIRDGD RIYATINGIG LSNDGKGKFV
LNPNPKGQIL AFERAYKNAG INPNSIDYIE CHATGTPIGD ITELNSMDAF FSRYQASPLI
GSVKSNFGHL LTTAGMTGLI KVILSMNQGV IPPTINLIEP LSSDNGGICA NQIVNATIPW
PNNTSTKRAA VSAFGFGGTN AHLILESSKP ENLDLGLTTE NLTKPTSSQN RLAIVGMDAC
FSSCEDLDDF DRTIYEAQQH FIPVPPQRWK GIELQPELLQ DYGFTDGKAP DGAYIQDFDL
DFLRFKIPPI EEDQLIPQQL LMLKVADNAI KDAGIIAGEN VAVIIAMGTE LALHQYLGRI
DLTWQIPATL KKENIGLSTQ KIAELETIVK SSLYPEARVN NYTSFIGNIM AARIAALWDF
SGPAFTVSAE ENSVFKSLEI AQMLLSQGEV DAVVVGAVDL AGGFENVLLR HQLAPINTGT
HTLSYDINAN GWMVGEGAGA VVLKRYETAQ QQQERIYAVI DAIALVQNNS QDKFPESVQQ
VCQQAFNLAN IQPQDIGYLE VFGSGIAQED TAEITGLNLA YRHNKTSQND TLTCCIGSIK
ANIGHTYAAS GIASLIKTAL CLYHRYIPAT PQWSKPKHLE HWQDSIFYVA NESRTWFLDE
GVSKRIAAIN GLGLDGTYAH LIISEETSQQ ERPSKYLAQT PFYLFPLAAD NQTALLAEIN
KLKQQIENTE CLATTATQTY QNFQQNIQAN YKLAIVGHHR EELLKEINLA IHSIDKAFQQ
TGEWKTPLGS YFTANPLAKK GKIAFVYPGM GSADIGLGKD IFRLFPQVYN TFSNSVSNIS
QSLCEKLIYP RSLTQLSEVG QAAKIDKFFN DGVAMCLSSI SLASLYTLIL QDYFQVQPQV
ACGYSLGEAS GMLFALRVWN PQYHSYATSA TAALMESPLF KTQLCGACVV GRQFWGLPLT
QKAGEEKFWT SYLLKASVLE VVEILKQENQ VYLTFINTPQ EVVIAGNPQS CLRVIKKLKC
RYITINFDSI LHCEIVQSVY NDIVKLHTIP IQNTPNIDFY SGVTADRLVI DTNSLAHNSA
TLCCQKVDFP QLINRLYQDG VRIFIEVGAK NNCSRWIDDN LKELEHIAIA INNKGVDDHT
NIVRLLATII SHNVSVNLLH LYSPLMKTSS PRTSIIKNII IGGSHIYSSI VNDENKSIFE
LPVTSHKICN QLPAKNINQR VMFTPSSSIN NLKIIQLQIA VSEQKLNSNI ATQKHMSNAN
INTLNSNNSI NAYTKPSNIV WNEADLLEFA QGNIASIFGQ DYQTIDSYSR RVRLPMPPYL
LVSRVTKIDA EKGRFKPCSM TTEYDIPHDA WYSVDGQIPL CVAVESGQCD LLLISYLGID
FENKGDLVYR LLDCTLTFLD DFPKEGETLR YDIKINSFVR SGDNLLFFFS YECFVGEKMV
LKMDGGCAGF FSDQQLEQGK GIIFTDKELA QRSQIQKQYF EPLLICQKST FDESDMLNLT
EGNIAACFGD SYCQYGLNPS LRLPPKAILM IDRVTSIETT GGVWGLGLII GEKNLDPEHW
YFPCHFKDDQ VMAGSLMAEG CSHLLEFYML YLGLQTYTTD ARFQPIPNLP QVVRCRGQVT
PVSAKLIYRM EITEIGLTPK PYVKCNVDII LHGKTIVHFQ DLGLQLSEKN PENSTHTNHL
VKTASTQLKT QKPTLLNEEQ VQEFCTGSAA KCFGSEYGIY DQGTVIASRM PNTHLQLVHR
VLEVKGQRHQ FTKGSTIVTE YDAPLDPWYY RQNSSETIPY SILMEIGLQP CGFLSAYLGT
TLLYPNQSLC FRNLDGKGYL TKNIDIRGKT ITNTSTLLSS INMKGNILQS FEFKVACDGE
IFYTGDASFG YFSPEALANQ VGLDRGQDVR PWYETQNTLN LPEIQIDLRT PESRNQYYQV
NSIRPNYRLA QYQLDLLHEL KIIAGGGNYH QGYIYATKEV KPTDWYFKCH FYLDPVMPGS
LGVEAILQAM QAYALHLDLG KYMKSPRFVP VIDHQVIWKY RGQIPHTQTQ MYLEIHISRL
EITEDKVTLV GDASLWKPNL RIYEIKDVAI CLVESNL
//
