ID K9RTJ0_SYNP3 Unreviewed; 624 AA.
AC K9RTJ0;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:AFY60788.1};
GN OrderedLocusNames=Syn6312_1628 {ECO:0000313|EMBL:AFY60788.1};
OS Synechococcus sp. (strain ATCC 27167 / PCC 6312).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=195253 {ECO:0000313|EMBL:AFY60788.1, ECO:0000313|Proteomes:UP000010379};
RN [1] {ECO:0000313|Proteomes:UP000010379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27167 / PCC 6312 {ECO:0000313|Proteomes:UP000010379};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP003558; AFY60788.1; -; Genomic_DNA.
DR AlphaFoldDB; K9RTJ0; -.
DR STRING; 195253.Syn6312_1628; -.
DR KEGG; syne:Syn6312_1628; -.
DR PATRIC; fig|195253.3.peg.1657; -.
DR eggNOG; COG0668; Bacteria.
DR HOGENOM; CLU_027053_1_0_3; -.
DR OrthoDB; 9809206at2; -.
DR Proteomes; UP000010379; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000010379};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 215..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 440..504
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 509..597
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 602..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 69446 MW; 3F5913526A54C85C CRC64;
MTQTHRKNWN QTRLLLRFGI PGWGKFLLLL TLSFLLVVGL ELPSWGQFTM PGLGNNNTNN
PPSNVIRSGD IEIARVMLDG SPLFFVTAPT VLDRDNPGDQ MPVEIRAELI EFSLQRVLTS
NEIGTPNPNL IFTTLDPKKI LVGVATLNKE TVISVRTNEL QNPQKILTVT ATDSLFYGMP
IADLAEDWRG RIQTALRQAA HDRSPQALTN YFQKSFHALL ILLALSVGLF WLKRYLKGRL
KHLKEQFEFV QAGSTPEPDH QSISSVTNPL KVPTQSSNAI NRWLSQQLSS PKLYLLDKRI
KITALGLFIL TWGQVAIWLI GGVYIFNLFP WTRYFAWRFL GLPISWLVIW FVSGLVNSLG
DLALKRLGQI WHNYPKGDTD IQRSALRIGT TLTVLGDLKT TIVYGVALGL VIGSLGIPVG
SVIAIGGLLA FALSLGAQSL VRDLINGAFI IWEDQFGIGD VVVIGDVSGA VENMNLRITQ
LRNGEGRLIT IPNSAISVVE NLTRTWSRVD FTIDIDSQTP AHQALDCLKQ VTTELYTDPA
WHEKILEPPE VLGIEQLTHS GLSIRIWIKT KPGQQWAVGR ELRQRVQRTM LKAGLEIGRP
QQTLINPQNG KINGLSHQQA NDPS
//
