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Database: UniProt
Entry: K9RZG6_SYNP3
LinkDB: K9RZG6_SYNP3
Original site: K9RZG6_SYNP3 
ID   K9RZG6_SYNP3            Unreviewed;       290 AA.
AC   K9RZG6;
DT   06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2013, sequence version 1.
DT   13-NOV-2019, entry version 34.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   OrderedLocusNames=Syn6312_3430 {ECO:0000313|EMBL:AFY62457.1};
OS   Synechococcus sp. (strain ATCC 27167 / PCC 6312).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae;
OC   Synechococcus; unclassified Synechococcus.
OX   NCBI_TaxID=195253 {ECO:0000313|EMBL:AFY62457.1, ECO:0000313|Proteomes:UP000010379};
RN   [1] {ECO:0000313|Proteomes:UP000010379}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27167 / PCC 6312 {ECO:0000313|Proteomes:UP000010379};
RX   PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA   Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E.,
RA   Calteau A., Cai F., Tandeau de Marsac N., Rippka R., Herdman M.,
RA   Sivonen K., Coursin T., Laurent T., Goodwin L., Nolan M.,
RA   Davenport K.W., Han C.S., Rubin E.M., Eisen J.A., Woyke T., Gugger M.,
RA   Kerfeld C.A.;
RT   "Improving the coverage of the cyanobacterial phylum using diversity-
RT   driven genome sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP003558; AFY62457.1; -; Genomic_DNA.
DR   RefSeq; WP_015125994.1; NC_019680.1.
DR   STRING; 195253.Syn6312_3430; -.
DR   EnsemblBacteria; AFY62457; AFY62457; Syn6312_3430.
DR   KEGG; syne:Syn6312_3430; -.
DR   PATRIC; fig|195253.3.peg.3471; -.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   OrthoDB; 1280729at2; -.
DR   BioCyc; SSP195253:G1HCL-3332-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000010379; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010379};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010379}.
FT   DOMAIN        4    187       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      209    286       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        186    186       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   290 AA;  32101 MW;  DFA02628478FE898 CRC64;
     MPITLAHLGP AGTYAEMAAL AFGNTLSLKH PETFDLHPYP SIAQSLQALD RGEVHYAIVP
     VENSLEGSVN MTLDTLWQLK HIQITQALVL PISHAFVTQA TDLTKVQNVY SHPQALGQCQ
     PWLQEFLPQA SQIPTNSTSA ALSYLTTDPT TAAITSIRAA QLHHLPIFAR DIQAYPLEAD
     TPMNCTRFWV MKPRETDGWP QAGDSYTSLA FSLPNNCPGA LVNALMIFAQ RNINLSRIES
     RPSKRSLGDY LFFLDLEVGE KREIVHTALE ELQAHTEVLH VWGSYSIAMV
//
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