ID K9SXM5_9SYNE Unreviewed; 2425 AA.
AC K9SXM5;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:AFY74910.1};
GN ORFNames=Syn7502_03001 {ECO:0000313|EMBL:AFY74910.1};
OS Synechococcus sp. PCC 7502.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=1173263 {ECO:0000313|EMBL:AFY74910.1, ECO:0000313|Proteomes:UP000010385};
RN [1] {ECO:0000313|EMBL:AFY74910.1, ECO:0000313|Proteomes:UP000010385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7502 {ECO:0000313|EMBL:AFY74910.1,
RC ECO:0000313|Proteomes:UP000010385};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Davenport K.,
RA Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y., Chain P.,
RA Chen A., Krypides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L., Peters L.,
RA Pitluck S., Woyke T., Kerfeld C.;
RT "Finished chromosome of genome of Synechococcus sp. PCC 7502.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP003594; AFY74910.1; -; Genomic_DNA.
DR RefSeq; WP_015169561.1; NC_019702.1.
DR STRING; 1173263.Syn7502_03001; -.
DR KEGG; synp:Syn7502_03001; -.
DR PATRIC; fig|1173263.3.peg.3112; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_3_3; -.
DR OrthoDB; 473401at2; -.
DR Proteomes; UP000010385; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000010385}.
FT DOMAIN 998..1073
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2051..2126
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2425 AA; 275749 MW; C8003682C6E9943B CRC64;
MHLDSINQRL ANLSPKKRQI LSDRLSKLAN TSKRLIAPRP IDFPCLASFA QQRFWFVQQL
FPQSSVYNNS RTLKFTQPAN IKAINKALYA IIDRHEVLRT TYKMEDDGKL YQIIHSVDAI
NIPIPIIDLS DRHEYLEAEV RKHTNQPFNL SFDFPLRNIL FKLNGEEYTL LIVIHHIASD
RWSSQIFLTE LNYFYETFLT DQPSILPALS IQYADFSIWQ RTQFSQNKFQ KQLDYWKAKL
KDQVSTINLP TDYPRPHISS NQGQSISITI SKPLTNALKI LSQSSGVTLF ITLLTAFKIL
LYRYSHQTDI TVGTPISGRN NLETEHLIGC FLNTLPLRTK ILETLSFKEL LSQVRATVLE
AQSHQEIPFE KVIEELKIER DLSYSPLFQV LFNFHNLPKV EQKASQSWFN ISTFDSRTTE
FDLAITLREI ESELVGTFIY STDLFKDITI AGMKNHYENL LQSIVDNPDR SISTIPFLTF
SEQVKILKQW NDTFAEYPHD KCIHQLFEEQ VERTPKNIAV VFEDQEITYR ELNNRANQLA
CHLQTLGVKP EVLVGICVER SIEMIVGLLG ILKAGGAYVP LDPAYPQERL DYLVKDAQLD
NPIVSQTNLT FKFASCTNIV DLERDQKMIA QQSTQNLKSD ITSENLAYVI YTSGSTGNPK
GVQIRHSNVV NLLSNICPKL NLTCEDTVCT LTTIAFDVAV SEIFLTLMIG ARLRIVSSEV
AKDGYQLAEV IRRSPITFMI STPATWQMLL TVGWQGSNQL KVIVTGEALS QELASRLLPK
TKELWNLYGP TETTIWSSFY LVKSSTKSPP IGRPLPNVTA YILDAYLQPV PIGVLGELHI
GGHGLARGYL NRPELTNQKF IANPFGEGKV YKTGDLARYM PDGNIEFIGR IDNQVKIRGF
RIELGEIEAV LSKHPDIINA VAIAREDIPG DKRIVAYVVS QVTLSQRELR EFLKQKLPEY
MIPSTFVILE QLPLTPSGKI DRRALPKPEI SRETEFSPPS NRTEEIITSI WSEVLGIPEV
DRRDNFFEIG GHSLLATQVI SRLQIALKQE ISIRSLFEHP TPVQLAEAIE QKYHLETTLT
IIEPLKNREN LPLSFAQFRM WFLYQLEGES ATYNVPLVLK LEGNLNIKSL EKAFQTIVDR
HEIFRTSFNT IDGSPVQIIA PSLQVTLSVI DLTELAELSV QKQVEELAHA ESNHTFKLTV
SPLFRAKILK LKENSHILLM NFHHIIIDGW SMGILRSELS ILYQNFIDGE SVSLAPLPIQ
YADFSYWQKN WLQGEVLTQQ LSYWKQQLAN IPAILELPTD RPRPNVQTYR GKSQKIKLSA
EVSQRLRDLS QESGVTLFMT LLSAFGILLS RYSHQENIVI GSPIANRNRQ ETEKLIGFFA
NTLALKISIK NNPSFKELLK SVKEVCLDAY SHQDLPYEKL VEELKPERSL SHAPVFQVMF
ILQNTPQETL TLPDLTLQSI ELKSQTSKFD ISLSLTESRA GIMGTWEYNT DLFDDTTIEG
MSSHFQVLLA GIIAEPDLQV KKLPILTEQE KHQLLIEWND TSKEYPHDKC IHQLFEEQVE
RTPENIAVVF EDQQITYREL NNRVNQLGHY FQTLGVKPEI LVGICVERSI EMIVGLLGIL
KAGGAYVPLD PNYPKERLQF ILDDIQTPFL LTQHSLLGNL SLDKFQVIYL DTDLEEINGE
DQDNPNCGTI PTDLAYIIYT SGSTGKPKGV CTIHRSVVRL VKGIDYVNLN SLQTFLQLAP
LAFDASTFEI WGSLLNGSRL VIFPPHAPSL QKLGQVIQQH QISTLWLTSG LFNLMVDNHI
EDLKPIRQLL AGGDVLSIPH VQKALSTLKN CHLINGYGPT EGTTFTCTHL ISETTHFRSS
VPIGRPISNT QVYILDRYMQ LVPIGVSGEL YIGGDGLARS YLNQPELTAE KFIANPFGNG
KLYKSGDVAR YLPDGNIEFI GRIDNQVKIR GFRIELGEIE AVLSKHPDII NAVAIAREDI
PGDKRIVAYI VSQVTLTNNK LRNFLKGQLP EYMTPSAFVF LDQFPLNANG KVDRSALPNP
QSSMTTNNFI PPRDRTEQQL ATIWEKHLNH HPISINDNFF DLGGHSLLSI RLVLDIEKAF
NCTLPLMSFF KLSTIEELAL WLRRHEQETM EIPSGLTLKY YRDLLAHSAG RQGNHIGRRG
LIVEVMPNID NAYGTNSQPF VWIGDIKVAK NLRLQQPIYV MPTFSHQTLV DSQEEYIEIE
AIASLLVDEL LTVHTSDSFM LGGYCFEGLI AIEMANQLKK RRKEITLLVL LETYPKPSIL
YKLCERLDQF ISIIKLLLLL SIDDKWHYLI DRINKYLNPK VQSKPTIANP SIADMGSKIY
NRRPYNDRVL LFMGTRKIRF IVKENPLFCS DFSWLFPYYG WERLLKGDVT VIKIPCGHDI
ISQPNIEYLS PILDQKIMEI CNEST
//
