ID K9VJW8_9CYAN Unreviewed; 606 AA.
AC K9VJW8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Protease 4 {ECO:0000256|PIRNR:PIRNR001217};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR001217};
DE AltName: Full=Endopeptidase IV {ECO:0000256|PIRNR:PIRNR001217};
DE AltName: Full=Protease IV {ECO:0000256|PIRNR:PIRNR001217};
DE AltName: Full=Signal peptide peptidase {ECO:0000256|PIRNR:PIRNR001217};
DE Flags: Precursor;
GN ORFNames=Osc7112_3906 {ECO:0000313|EMBL:AFZ08246.1};
OS Oscillatoria nigro-viridis PCC 7112.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Oscillatoria.
OX NCBI_TaxID=179408 {ECO:0000313|EMBL:AFZ08246.1, ECO:0000313|Proteomes:UP000010478};
RN [1] {ECO:0000313|EMBL:AFZ08246.1, ECO:0000313|Proteomes:UP000010478}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7112 {ECO:0000313|EMBL:AFZ08246.1,
RC ECO:0000313|Proteomes:UP000010478};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Davenport K.,
RA Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y., Chain P.,
RA Chen A., Krypides N., Mavromatis K., Markowitz V., Szeto E., Ivanova N.,
RA Mikhailova N., Ovchinnikova G., Pagani I., Pati A., Goodwin L., Peters L.,
RA Pitluck S., Woyke T., Kerfeld C.;
RT "Finished chromosome of genome of Oscillatoria sp. PCC 7112.";
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|PIRNR:PIRNR001217}.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683, ECO:0000256|PIRNR:PIRNR001217}.
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DR EMBL; CP003614; AFZ08246.1; -; Genomic_DNA.
DR RefSeq; WP_015177497.1; NC_019729.1.
DR AlphaFoldDB; K9VJW8; -.
DR KEGG; oni:Osc7112_3906; -.
DR PATRIC; fig|179408.3.peg.4813; -.
DR eggNOG; COG0616; Bacteria.
DR HOGENOM; CLU_008856_1_1_3; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000010478; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR Gene3D; 6.20.330.10; -; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|PIRNR:PIRNR001217};
KW Cell membrane {ECO:0000256|PIRNR:PIRNR001217};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001217};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR001217};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR001217};
KW Reference proteome {ECO:0000313|Proteomes:UP000010478};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..286
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 386..534
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 202
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 400
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 606 AA; 66408 MW; 32185E5357A7AA5D CRC64;
MKDFLKYTCA SLLGTFLGLL LLGSIGLGGL VLLIALAASS SKDSGPQVKD KSVLVLDLSL
NITDSKPIRS TSAAIEEVLS EDSGDTVTLR TVLDTIEYAK KDPKIVGIYL EGSSDSGRSG
FANLKEVRSA LQRFRDAKKP IFAYQMDWNE RDYYLGSVAN TIAVNPYGAL EINGFSSQGM
FFTGALEKYG VGVQVTRVGK YKSAVEPFLL TKMSPENRQQ TQKLLGDMWG EYLKTVAPSR
KVTVGQLQAL ADNGGTLMAD EALKNKLVDK VVYFDEISTE LKKLTGTDRE NKSFKQISLK
NYARIAENKN STRADNKNQI AILYAEGEIV DGEGGPTEVG GDRIAQEMRK IREDNDVKAV
VLRVNSPGGS ATAAEVIGRE VMLTGKKKPV IVSMGNLAAS GGYWISMGSN RIFAEPNTIT
GSIGVFGMLF NAEKLAANNG LTWDVVKTAR FADTNTVSRP KNPQELANIQ RIVDRIYDRF
ITKVANSRKL PKNKVQEIAQ GRVWSGTAAK ELGLVDEIGG LEDAVREAAK QAKLGDDWKL
EEYPKRRTLE ERILEKISGV HVLKPAAKLD PLTAEFKKMQ DELAVIKSMN DPQGVYVRLP
FNLRID
//
