ID K9WJV8_9CYAN Unreviewed; 692 AA.
AC K9WJV8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=Mic7113_4814 {ECO:0000313|EMBL:AFZ20483.1};
OS Allocoleopsis franciscana PCC 7113.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Coleofasciculales;
OC Coleofasciculaceae; Allocoleopsis; Allocoleopsis franciscana.
OX NCBI_TaxID=1173027 {ECO:0000313|EMBL:AFZ20483.1, ECO:0000313|Proteomes:UP000010471};
RN [1] {ECO:0000313|EMBL:AFZ20483.1, ECO:0000313|Proteomes:UP000010471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7113 {ECO:0000313|EMBL:AFZ20483.1,
RC ECO:0000313|Proteomes:UP000010471};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Chen A., Kyrpides N.,
RA Mavromatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Pati A.,
RA Goodwin L., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T., Kerfeld C.A.;
RT "Finished chromosome of genome of Microcoleus sp. PCC 7113.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP003630; AFZ20483.1; -; Genomic_DNA.
DR AlphaFoldDB; K9WJV8; -.
DR STRING; 1173027.Mic7113_4814; -.
DR REBASE; 58100; M.Msp7113ORF4814P.
DR KEGG; mic:Mic7113_4814; -.
DR PATRIC; fig|1173027.3.peg.5339; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_012122_0_0_3; -.
DR OrthoDB; 467945at2; -.
DR Proteomes; UP000010471; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFZ20483.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010471};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFZ20483.1}.
FT DOMAIN 7..145
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 164..466
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 692 AA; 80849 MW; D6BE2406CC0DB213 CRC64;
MADHHQLSNF IWQIADLLRG PYRPPQYERV MLPMTVLRRF DCVLAPTKQQ VLAEAAKWEE
KFKGNDAALD PILNKAVGKG FRFHNRSPLD FEKLKGDPDN IDKHLISYIE SFSKNVRDIF
EKFEFTNEVE RMREANILYL VVSKFCDVDL HPGTDDAPKV DNIAMGLLFE DLIRRFNEAA
NETAGDHFTP REVIRLMVDI LFDPDDDILT KPGIVSKLLD PACGTGGMLA EAQNYLRREY
NSEARLYVYG QDFNPRAYAI AASDLLMKGN ENSAIRFGDS LIDDQYPDDR FDYLLANPPF
GVDWKKQQKE VKREHEKQGF AGRFGAGLPR INDGALLFLQ HMISKFELYQ PTQNKFGSRL
AIVFNGSPLF TGGAGSGESE IRRWIIENDW LEAIIALPEQ MFYNTGIGTY LWIVTNRKQS
HRKGKIQLID ARARWQPMRR SLGDKRRYMG EDDIAAVVCE YGKFVETETS KIFDNEDFGY
NRVPIERPLR LVYQMNTDRK SRFLDAVPHL LDDVQAIDRE LGREPREDWS EFDRLMKKLL
KQRESRWKNP ERKLFRDVFT ERDPEAKPVI LDQREAKGDP NARIWGWFPV PNRKLERMYE
PDSQLRDFEN VRLVDTENPE KNEKEIIHYF CHEVEPHLSD SWADKQKIRS AYEINFNRHF
YKYTPPRSLE DIDADIKKME AEIIRLLHEV TS
//
