ID K9WZG2_9NOST Unreviewed; 895 AA.
AC K9WZG2;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=Cylst_3015 {ECO:0000313|EMBL:AFZ25186.1};
OS Cylindrospermum stagnale PCC 7417.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae;
OC Cylindrospermum.
OX NCBI_TaxID=56107 {ECO:0000313|EMBL:AFZ25186.1, ECO:0000313|Proteomes:UP000010475};
RN [1] {ECO:0000313|EMBL:AFZ25186.1, ECO:0000313|Proteomes:UP000010475}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7417 {ECO:0000313|EMBL:AFZ25186.1,
RC ECO:0000313|Proteomes:UP000010475};
RG US DOE Joint Genome Institute;
RA Gugger M., Coursin T., Rippka R., Tandeau De Marsac N., Huntemann M.,
RA Wei C.-L., Han J., Detter J.C., Han C., Tapia R., Chen A., Kyrpides N.,
RA Mavromatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Pati A.,
RA Goodwin L., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T., Kerfeld C.A.;
RT "Finished chromosome of genome of Cylindrospermum stagnale PCC 7417.";
RL Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP003642; AFZ25186.1; -; Genomic_DNA.
DR RefSeq; WP_015208439.1; NC_019757.1.
DR AlphaFoldDB; K9WZG2; -.
DR STRING; 56107.Cylst_3015; -.
DR REBASE; 58129; Cst7417ORF3015P.
DR KEGG; csg:Cylst_3015; -.
DR PATRIC; fig|56107.3.peg.3308; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_005831_1_1_3; -.
DR OrthoDB; 564694at2; -.
DR Proteomes; UP000010475; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046819; MmeI_hel.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046817; MmeI_N.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF6; DNA METHYLTRANSFERASE A; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20465; MmeI_hel; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20464; MmeI_N; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AFZ25186.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010475};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..181
FT /note="MmeI-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF20464"
FT DOMAIN 188..258
FT /note="MmeI-like helicase spacer"
FT /evidence="ECO:0000259|Pfam:PF20465"
FT DOMAIN 336..565
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 597..797
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
SQ SEQUENCE 895 AA; 102964 MW; 34B2319122C9EE8B CRC64;
MAAATPESLA KFVSFCQQHI TGQERKEAQT FLDRLFRAFG HEGALEAGAN YEEAIKKGSK
QGKTGFADLV WKPRVLIEMK KRGEDLSKHY SQAFDYWTRL VPNRPKYVIL CNFDEFWIFD
FDLQLDTPVD KITLEQLPER AGALVFMELG EKTPVFQNNQ VEVTVRAARR MGELLLELEK
RGIEKLTAQR FILQCVLAMF AEDRQLLPRD MFISCVQDCM KGASSYDVLG GLFREMNLPG
KTPAGRYQGV DYFNGGLFSL IHGIELTREE LNFLDVSARE NWSKIRPAIF GNLFEGTVDK
KERHARGIHY TSEADIMKIV RPTISRYWEE RIEAANTIGE LSTLQIELQS YRVLDPACGS
GNFLYIAYQE LKRIEILLLD KIQQRRKSED KQMQIGLVTP LQFYGMDTNP FAVELARVTL
MIARKIAIDN LNLTEPALPL DSLDNNIVCQ DALFSEWRQA NAIIGNPPFL GGNRIRLDLG
DKYAESIFSK FPEVKAQVDI CTYWFRLAHE NLNGKGRAGL VGTNSISQGN SRYVSLDYIT
RNGGYIHEAI STQNWSGEAK VHVSLVNWCY EEPSKFYLDY QDVKQISSSL RTTVDVSIAT
RLKSNLNRCF EGVKPNAKGF VITENQAQYW IKYNDKNKLV IKLFLDAGDL TKVPHGKPSR
WVIDFDNMNL EEASDYILPF EHVRVTVKPE RENNRESVLR ERWWRFKRTH AAMRQALTPL
KIYFTVPAHS KWFIFVPSFS NWLPNNSTKV VASDDFYILG ILTSKVHRVW VKAQSSTLKG
DTRYTHNTCF ETFPFPQTPD TKLVNQIRAK AEELHEYRTE QMESKQWGIT TLYNKFFNEP
TSQLYKLHSQ LDKLVMEAYD FNPKDDILEK LLGLNLELAE KEKQGIKIIG PWAPN
//
