ID K9XTR6_STAC7 Unreviewed; 615 AA.
AC K9XTR6;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=6-deoxyerythronolide-B synthase {ECO:0000313|EMBL:AFZ35459.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:AFZ35459.1};
GN OrderedLocusNames=Sta7437_1903 {ECO:0000313|EMBL:AFZ35459.1};
OS Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Pleurocapsales; Dermocarpellaceae;
OC Stanieria.
OX NCBI_TaxID=111780 {ECO:0000313|EMBL:AFZ35459.1, ECO:0000313|Proteomes:UP000010473};
RN [1] {ECO:0000313|Proteomes:UP000010473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29371 / PCC 7437 {ECO:0000313|Proteomes:UP000010473};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; CP003653; AFZ35459.1; -; Genomic_DNA.
DR RefSeq; WP_015193130.1; NC_019748.1.
DR AlphaFoldDB; K9XTR6; -.
DR STRING; 111780.Sta7437_1903; -.
DR KEGG; scs:Sta7437_1903; -.
DR PATRIC; fig|111780.3.peg.1991; -.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_16_2_3; -.
DR OrthoDB; 499075at2; -.
DR Proteomes; UP000010473; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AFZ35459.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000010473};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:AFZ35459.1}.
FT DOMAIN 30..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT COILED 8..35
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 615 AA; 67514 MW; 15CC7298DF84FF70 CRC64;
MTDNLSPTKR ALLALKQMQA KLEALENAKS EEIAIIGMGC RFPGGVNSPE SFWQLLCSGT
DAITEVPPQH WQIDSYYPKQ ICSRKGGFVP NLKEFDAQFF RIAPREAISL DPQQRLLLEV
SWEALENAAI APDSLSGSAT GVFIGICSID YWHQLLSRNN TEIDAYLTTG NTHSVAAGRL
SYTLGLTGPA IAVDTACSSS LVAVHLACQS LRNRECDLAL AGGVNRLISP EISINFSQAK
MLSPTGFCHS FDAKADGFVR SEGCGVIVLK RLSDAISSGD QILAVISGSA VNQDGRTSGL
TAPNGLSQQA VIRQALAKSQ IEPSQIDYLE THGTGTALGD PIEVNALGEV FNKREKPLIL
GSVKTNIGHT EAAAGIASLI KVVLSFQQQK IPANLHFQQP NHQINWHELP IQVATEMMPW
LNTNKPRMAG VSAFGFSGTN AHVVIQESVN RSRDVTCYVS TKGESQKALC QLFVLSAKSD
RALKDLVQRY LEFFKSNHDL SLEDVCFTAS VGRSHFNHRL AVMAISIQEL ERKLTAFLRE
ELQSGVWSGK FTKKVDNNVI KLNPIEFTTE ASLVEIAQLY VSGKTLDWFS FYQNSDYSKV
ALPTYPFQRQ TYWYQ
//
