ID K9YH83_HALP7 Unreviewed; 511 AA.
AC K9YH83;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=prolycopene isomerase {ECO:0000256|ARBA:ARBA00012419};
DE EC=5.2.1.13 {ECO:0000256|ARBA:ARBA00012419};
GN OrderedLocusNames=PCC7418_3748 {ECO:0000313|EMBL:AFZ45852.1};
OS Halothece sp. (strain PCC 7418) (Synechococcus sp. (strain PCC 7418)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Halothecacae; Halothece cluster; Halothece.
OX NCBI_TaxID=65093 {ECO:0000313|EMBL:AFZ45852.1, ECO:0000313|Proteomes:UP000010481};
RN [1] {ECO:0000313|Proteomes:UP000010481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7418 {ECO:0000313|Proteomes:UP000010481};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene;
CC Xref=Rhea:RHEA:30971, ChEBI:CHEBI:15948, ChEBI:CHEBI:62466;
CC EC=5.2.1.13; Evidence={ECO:0000256|ARBA:ARBA00000004};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- COFACTOR:
CC Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC Evidence={ECO:0000256|ARBA:ARBA00001937};
CC -!- PATHWAY: Carotenoid biosynthesis; lycopene biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane
CC {ECO:0000256|ARBA:ARBA00004258}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004258}.
CC -!- SIMILARITY: Belongs to the carotenoid/retinoid oxidoreductase family.
CC CrtISO subfamily. {ECO:0000256|ARBA:ARBA00005855}.
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DR EMBL; CP003945; AFZ45852.1; -; Genomic_DNA.
DR RefSeq; WP_015227724.1; NC_019779.1.
DR AlphaFoldDB; K9YH83; -.
DR STRING; 65093.PCC7418_3748; -.
DR KEGG; hao:PCC7418_3748; -.
DR PATRIC; fig|65093.3.peg.3956; -.
DR eggNOG; COG1233; Bacteria.
DR HOGENOM; CLU_019722_4_1_3; -.
DR OrthoDB; 416321at2; -.
DR Proteomes; UP000010481; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046608; F:carotenoid isomerase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016117; P:carotenoid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.90.660.50; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR014101; CrtISO.
DR InterPro; IPR045892; CrtISO-like.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR NCBIfam; TIGR02730; carot_isom; 1.
DR PANTHER; PTHR46313; -; 1.
DR PANTHER; PTHR46313:SF3; PROLYCOPENE ISOMERASE, CHLOROPLASTIC; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Isomerase {ECO:0000313|EMBL:AFZ45852.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:AFZ45852.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010481}.
FT DOMAIN 27..505
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 511 AA; 57181 MW; B54CC0322756F8B8 CRC64;
MTTVSGNPAP TATEVRVYDA IVIGSGIGGL VTATQLAAKG ANVLVLERYI IPGGSAGYFE
RQGYRFDVGA SMIFGLGTQG TTNLLTRALE AVDTSLETIP DPVQIDYHLP NDLEIRVHRD
YEQFIQELIA KFPHEAEGIR QFYDECWRVF NCLNAMELLS LEEPRYLTRV FFQHPFACLG
LVKYLPQNVG DIARRYISDP TLLKFIDIEC YCWSVVPAAK TPMINAGMVF SDRHYGGINY
PKGGVGQIAQ KLVEGFEKKG GTIQYKARVK EIILENNKAV GVRLADGTEY RGQRIISNAT
RWDTFEKLLP QQTLPKKEQK WQQRYQKSPS FLSLHLGVKA GVVPEGTDCH HILLENWEQM
EEPERTIFLS IPTLLDPSLA PPNCHIFHTF TPAWIEDWQG LSPQDYHEKK EQAAARIIKR
LEKIFPGLEA ALDYQEVGSP RTHRRFLGRE DGTYGPIPQK KLMGLLGMPF NQTVIPGLYC
VGDSTFPGQG LNAVAFSGFA CAHRVGVDLG M
//
