ID K9YPH8_CYASC Unreviewed; 812 AA.
AC K9YPH8;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits {ECO:0000313|EMBL:AFZ48367.1};
GN OrderedLocusNames=Cyast_2421 {ECO:0000313|EMBL:AFZ48367.1};
OS Cyanobacterium stanieri (strain ATCC 29140 / PCC 7202).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Geminocystaceae; Cyanobacterium.
OX NCBI_TaxID=292563 {ECO:0000313|EMBL:AFZ48367.1, ECO:0000313|Proteomes:UP000010483};
RN [1] {ECO:0000313|Proteomes:UP000010483}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29140 / PCC 7202 {ECO:0000313|Proteomes:UP000010483};
RX PubMed=23277585; DOI=10.1073/pnas.1217107110;
RA Shih P.M., Wu D., Latifi A., Axen S.D., Fewer D.P., Talla E., Calteau A.,
RA Cai F., Tandeau de Marsac N., Rippka R., Herdman M., Sivonen K.,
RA Coursin T., Laurent T., Goodwin L., Nolan M., Davenport K.W., Han C.S.,
RA Rubin E.M., Eisen J.A., Woyke T., Gugger M., Kerfeld C.A.;
RT "Improving the coverage of the cyanobacterial phylum using diversity-driven
RT genome sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:1053-1058(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP003940; AFZ48367.1; -; Genomic_DNA.
DR AlphaFoldDB; K9YPH8; -.
DR STRING; 292563.Cyast_2421; -.
DR KEGG; csn:Cyast_2421; -.
DR PATRIC; fig|292563.3.peg.2526; -.
DR eggNOG; COG0842; Bacteria.
DR eggNOG; COG1131; Bacteria.
DR eggNOG; COG1716; Bacteria.
DR HOGENOM; CLU_012042_0_0_3; -.
DR BioCyc; CSTA292563:G1353-2424-MONOMER; -.
DR Proteomes; UP000010483; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00060; FHA; 2.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000010483};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 554..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..95
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 146..195
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 235..466
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 812 AA; 90664 MW; F35732F1A95A094E CRC64;
MNQSFSSNTV LESSLNPYII LNNQGITLPP MELFAPEHRL GRDPQMVDLL APTDWNIVSR
CQGKFVRGEN NTYRIYDGDG QKRSSNGLFV NNRLISPQGH LLRNGDRIQI GQNPRDWVII
EYHSSMTSSG FTPPPIQSVS LLEKPIILGR DENADLRLDA PTVSRKHAVI TKNNQGQYVL
TDYSANGVFV NEQKVNGSRV INQDSLINIG PYRLVLQGNR LVIADQGDNI RLDAFNLIRV
VKDQEGKDRT IINDISLPIE PGQFVALVGG SGAGKSTLMR TLLGIEPTTN GAVFINGEDL
RQNFNIYRNQ IGYVPQQDII HKDLTVVEAL EYSAKLRLPP DINIREIVSK TLHQIELVDY
KNILVKNLSG GQLKRVSIGA ELLADPKLFF LDEPTSGLDP GLDKKMMELL RKLADEGRTI
ILVTHATTNI NMCDRLVFLG RGGHLCYYGE PKGAMDFFDI SSENFADIYI NLETIEAVVN
KAQTFKNSSY YQENITNRLS LKNSNLSPQN NTITSVNHNQ VSRQMMPEKA KPSLVKQTIT
LSQRYAKIVF RDKVNLSISL LTAPIGISLI SLAIQIEPLV LGLDDNPKLA STALSVLFVF
ACANIWVGLS GSLQEIVKEA DIYFRERLVN LDIFAYLFSK LSVLKLVTFL QSILIVIVVL
LRFESPNSEL IYWSMGVFIT SFLTIFASIN FGLMVSAMVK NITQANSLLP LLLIPQIIFS
GVLFSMEDAG KYLSWLTISR WSVGAYGTLV DVNAMIPEPI ILPDGSAIAL GIPESLVYES
SWNNLMINWL VLILHTLIYF VVTFILQKRK DL
//
